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The effect of intercalating drugs on the kinetics of the B to Z transition of poly(dG-dC).嵌入药物对聚（dG-dC）从B型到Z型转变动力学的影响。
Nucleic Acids Res. 1983 Mar 25;11(6):1931-41. doi: 10.1093/nar/11.6.1931.
2
Reaction of nucleic acids and cis-diamminedichloroplatinum(II) in the presence of intercalating agents.核酸与顺二氯二氨合铂（II）在嵌入剂存在下的反应。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6317-21. doi: 10.1073/pnas.83.17.6317.
3
Binding of ethidium and bis(methidium)spermine to Z DNA by intercalation.溴化乙锭和双（甲溴化）精胺通过嵌入作用与Z-DNA结合。
Nucleic Acids Res. 1984 Jun 11;12(11):4679-90. doi: 10.1093/nar/12.11.4679.
4
Base protonation facilitates B-Z interconversions of poly(dG-dC) X poly(dG-dC).碱基质子化促进了聚（dG-dC）×聚（dG-dC）的B-Z相互转换。
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Inhibition of the B to Z transition in poly(dGdC).poly(dGdC) by covalent attachment of ethidium: equilibrium studies.通过溴化乙锭的共价连接抑制聚（dGdC）·聚（dGdC）中B型向Z型的转变：平衡研究
Biochemistry. 1991 Nov 12;30(45):10925-31. doi: 10.1021/bi00109a017.
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Interaction of drugs with Z-DNA: cooperative binding of actinomycin D or actinomine to the left-handed forms of poly(dG-dC).poly(dG-dC) and poly(dG-m5dC).poly(dG-m5dC) reverses the conformation of the helix.药物与Z-DNA的相互作用：放线菌素D或放线诺明与聚（dG-dC）·聚（dG-dC）和聚（dG-m5dC）·聚（dG-m5dC）的左手形式的协同结合会使螺旋构象发生逆转。
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7
Inhibition of the thermally driven B to Z transition by intercalating drugs.嵌入药物对热驱动的B型到Z型转变的抑制作用。
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Characterization of the ternary complexes formed in the reaction of cis-diamminedichloroplatinum (II), ethidium bromide and nucleic acids.顺二氯二氨合铂（II）、溴化乙锭与核酸反应中形成的三元复合物的表征。
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Bromination stabilizes poly(dG-dC) in the Z-DNA form under low-salt conditions.在低盐条件下，溴化作用可使聚（dG-dC）稳定于Z-DNA形式。
Biochemistry. 1984 Jan 3;23(1):54-62. doi: 10.1021/bi00296a009.
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Effect of intercalative binding compared to external binding on Z/B equilibrium of poly d(GMe5C) using fluorescent oxazolopyridocarbazoles as probes.以荧光恶唑并吡啶咔唑为探针，比较嵌入结合与外部结合对聚d（GMe5C）的Z/B平衡的影响。
J Mol Recognit. 1989 Dec;2(4):152-7. doi: 10.1002/jmr.300020403.

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Modulation of DNA structure formation using small molecules.利用小分子调节 DNA 结构形成。
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Binding of ethidium and bis(methidium)spermine to Z DNA by intercalation.溴化乙锭和双（甲溴化）精胺通过嵌入作用与Z-DNA结合。
Nucleic Acids Res. 1984 Jun 11;12(11):4679-90. doi: 10.1093/nar/12.11.4679.
5
Conformational analysis of r(CGCGCG) in aqueous solution: an A-type double helical conformation studied by two-dimensional nuclear Overhauser effect spectroscopy.水溶液中r(CGCGCG)的构象分析：通过二维核Overhauser效应光谱研究的A型双螺旋构象
Nucleic Acids Res. 1984 May 25;12(10):4323-38. doi: 10.1093/nar/12.10.4323.
6
Daunomycin inhibits the B leads to Z transition in poly d(G-C).柔红霉素抑制聚 d(G-C) 中 B 型向 Z 型的转变。
Nucleic Acids Res. 1983 Dec 10;11(23):8485-94. doi: 10.1093/nar/11.23.8485.
7
The effect of adriamycin on Z-DNA formation and DNA synthesis.阿霉素对Z-DNA形成及DNA合成的影响。
Nucleic Acids Res. 1983 Dec 10;11(23):8415-20. doi: 10.1093/nar/11.23.8415.
8
Characterization of the ternary complexes formed in the reaction of cis-diamminedichloroplatinum (II), ethidium bromide and nucleic acids.顺二氯二氨合铂（II）、溴化乙锭与核酸反应中形成的三元复合物的表征。
Nucleic Acids Res. 1987 Feb 25;15(4):1779-97. doi: 10.1093/nar/15.4.1779.
9
Interactions of water soluble porphyrins with Z-poly(dG-dC).水溶性卟啉与Z-聚（dG-dC）的相互作用
Nucleic Acids Res. 1986 May 12;14(9):3927-43. doi: 10.1093/nar/14.9.3927.
10
Non-contiguous regions of Z-DNA in a DNA dodecamer.DNA十二聚体中Z-DNA的非连续区域。
Nucleic Acids Res. 1989 Oct 11;17(19):7923-44. doi: 10.1093/nar/17.19.7923.

本文引用的文献

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Left-handed double helical DNA: variations in the backbone conformation.左手双螺旋DNA：主链构象的变化
Science. 1981 Jan 9;211(4478):171-6. doi: 10.1126/science.7444458.
2
Crystal structure analysis of a complete turn of B-DNA.B型DNA完整一圈的晶体结构分析。
Nature. 1980 Oct 23;287(5784):755-8. doi: 10.1038/287755a0.
3
The high salt form of poly(dG-dC).poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions.聚（dG-dC）·聚（dG-dC）的高盐形式是左手Z-DNA：晶体和溶液的拉曼光谱。
Nucleic Acids Res. 1981 Oct 24;9(20):5443-57. doi: 10.1093/nar/9.20.5443.
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The transitions between left- and right-handed forms of poly(dG-dC).聚（dG-dC）左右手性形式之间的转变
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DNA structure and gene regulation.DNA结构与基因调控。
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7-Methylguanine in poly(dG-dC).poly(dG-dC) facilitates z-DNA formation.聚（dG-dC）·聚（dG-dC）中的7-甲基鸟嘌呤促进Z-DNA的形成。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4777-81. doi: 10.1073/pnas.78.8.4777.
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The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.四聚体d（CpGpCpG）结晶为左手双螺旋结构。
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Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes.抗左旋Z-DNA的抗体与果蝇多线染色体的间带区域结合。
Nature. 1981 Dec 3;294(5840):417-22. doi: 10.1038/294417a0.
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Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).甲基化对合成多核苷酸的影响：聚（dG-m5dC）·聚（dG-m5dC）中的B-Z转变
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Left-handed DNA in restriction fragments and a recombinant plasmid.限制性片段和重组质粒中的左手螺旋DNA
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嵌入药物对聚（dG-dC）从B型到Z型转变动力学的影响。

The effect of intercalating drugs on the kinetics of the B to Z transition of poly(dG-dC).

作者信息

Mirau P A, Kearns D R

出版信息

Nucleic Acids Res. 1983 Mar 25;11(6):1931-41. doi: 10.1093/nar/11.6.1931.

DOI:10.1093/nar/11.6.1931
PMID:6835844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC325847/
Abstract

We have measured the ability of the intercalating drugs proflavine, ethidium bromide, actinomycin D, and bismethidiumspermine to inhibit the salt induced transition of poly(dG-dC) from the B to the Z form. While all of the drugs studied slowed the B to Z transition, the effectiveness of the drugs correlates much better with their DNA binding kinetics than their DNA binding constants. In studies where the binding densities of ethidium and actinomycin were varied we have found that high levels of ethidium, more than 1 per 20 base pairs, were required to inhibit the B to Z transition while low levels of actinomycin, less than 1 per 450 base pairs, reduced the transition rate. Studies of the B to Z transition in the presence of both actinomycin and ethidium suggest that the drugs inhibit the transition by different mechanisms. The results are interpreted in terms of a modification of the kinetic model proposed by Pohl and Jovin in which, depending on the DNA binding kinetics of the drug, the drug may inhibit nucleation and/or propagation of the B to Z transition.

摘要

我们已测定了嵌入药物原黄素、溴化乙锭、放线菌素D和双甲脒精胺抑制盐诱导的聚（dG-dC）从B型向Z型转变的能力。虽然所研究的所有药物都减缓了B型向Z型的转变，但药物的有效性与其DNA结合动力学的相关性远高于其DNA结合常数。在改变溴化乙锭和放线菌素结合密度的研究中，我们发现，抑制B型向Z型转变需要高水平的溴化乙锭（每20个碱基对超过1个），而低水平的放线菌素（每450个碱基对少于1个）就能降低转变速率。在同时存在放线菌素和溴化乙锭的情况下对B型向Z型转变的研究表明，这两种药物通过不同机制抑制转变。根据Pohl和Jovin提出的动力学模型的修正来解释这些结果，其中，根据药物的DNA结合动力学，药物可能抑制B型向Z型转变的成核和/或传播。