Reisin E, Eliahou H E
Biomedicine. 1978 Apr;29(2):48-50.
Whether the same patient with essential hypertension (EH) has the same PRA profile at different occasions, is still uncertain. The validity of the classification of these patients into low or normal renin hypertension depends upon the reproducibility of this profile. A nomogram based on PRA and 24 hr urine sodium in normals, was constructed by computing the regression line with its tolerance limits of not less than 95%. In 30 patients with EH, the PRA and 24 hr urine sodium were determined in 2 separate occasions. Classification of patients showed a change of 30% when PRA was taken during at least 2 hours recumbency. However, when PRA following ambulation is considered, the change appeared only in 6/30 (20%). This change was not large. Thus good reproducibility of PRA is obtained on post-ambulation PRA and changes larger than the 95% tolerance limits, are considered.
原发性高血压（EH）患者在不同时间点的血浆肾素活性（PRA）情况是否相同仍不确定。将这些患者分为低肾素或正常肾素高血压的分类有效性取决于该PRA情况的可重复性。通过计算回归直线及其不低于95%的容忍限度，构建了基于正常人群PRA和24小时尿钠的列线图。对30例EH患者在两个不同时间点测定了PRA和24小时尿钠。当在至少2小时卧位时测定PRA时，患者分类显示有30%的变化。然而，当考虑活动后PRA时，变化仅出现在6/30（20%）的患者中。这种变化不大。因此，活动后PRA具有良好的可重复性，且考虑了大于95%容忍限度的变化。
