Linnet K, Mertz Nielsen A
Scand J Gastroenterol. 1983 May;18(3):433-8. doi: 10.3109/00365528309181619.
Fasting and postprandial serum concentrations of glycine and taurine conjugates of cholic, chenodeoxycholic, and deoxycholic acid were measured with a high-pressure liquid chromatographic-enzymatic assay in 17 patients with ileal Crohn's disease and in 17 controls. The postprandial concentrations of the taurine-conjugated bile acids in the patients were significantly lower than in the controls, whereas the concentrations of the glycine conjugates were not significantly different. The total glycine to taurine ratios of serum bile acids were significantly higher in the patients (means, 2.9 fasting and 4.8 postprandial) than in the controls (1.9 and 2.6). Of the patients, 65% had a postprandial total G/T ratio of serum bile acids which was above the control interval.
采用高压液相色谱 - 酶法测定了17例回肠克罗恩病患者和17例对照者空腹及餐后血清中胆酸、鹅去氧胆酸和脱氧胆酸的甘氨酸和牛磺酸共轭物浓度。患者中牛磺酸共轭胆汁酸的餐后浓度显著低于对照组，而甘氨酸共轭物的浓度无显著差异。患者血清胆汁酸的总甘氨酸与牛磺酸比值（空腹时均值为2.9，餐后为4.8）显著高于对照组（分别为1.9和2.6）。在患者中，65%的人血清胆汁酸餐后总G/T比值高于对照区间。
