Watanabe A, Oizumi K, Konno K
Jpn J Antibiot. 1983 Dec;36(12):3395-8.
The frequency and severity of side effects, above all, phlebitis, associated with an intravenous use of cephapirin (CEPR) or cephalothin (CET) was compared in 69 patients with infections. Two grams of each drug were administered intravenously twice a day with a 21-G vein needle in one of the two arms of the patients. CEPR was administered to 32 patients, and CET to 37 patients respectively. After treatment, the status of the veins was checked, and laboratory findings and other side effects were evaluated daily. Each drug appeared to be equally efficacious in the treatment of infections. The administration of CEPR was associated with a slightly lower rate of phlebitis and other side effects, but the difference between the 2 drugs was not significant (0.05 less than P less than 0.10). Phlebitis was observed in 1 patient (3.1%) of CEPR group and in 3 patients (8.1%) of CET group. Side effects, including phlebitis, were observed in 4 patients (12.5%) of CEPR group and in 12 patients (32.4%) of CET group. In CET group, drug exanthema (3 cases), drug fever (3 cases), and abnormalities in liver function (4 cases) were observed. These findings, together with the results of other reports, suggest that CEPR is a safe and useful drug in the treatment of infection as compared with CET.
在69例感染患者中，比较了静脉使用头孢匹林（CEPR）或头孢噻吩（CET）相关副作用的频率和严重程度，尤其是静脉炎。两种药物各2克，每天两次通过21G静脉针在患者双臂之一中静脉给药。分别对32例患者给予CEPR，37例患者给予CET。治疗后，检查静脉状况，每天评估实验室检查结果和其他副作用。每种药物在治疗感染方面似乎同样有效。CEPR给药相关的静脉炎和其他副作用发生率略低，但两种药物之间的差异不显著（0.05＜P＜0.10）。CEPR组有1例患者（3.1%）发生静脉炎，CET组有3例患者（8.1%）发生静脉炎。CEPR组有4例患者（12.5%）出现包括静脉炎在内的副作用，CET组有12例患者（32.4%）出现副作用。在CET组中，观察到药物疹（3例）、药物热（3例）和肝功能异常（4例）。这些发现与其他报告的结果一起表明，与CET相比，CEPR在治疗感染方面是一种安全有效的药物。
