Berger S, Ernst E C, Barza M
Antimicrob Agents Chemother. 1976 Apr;9(4):575-9. doi: 10.1128/AAC.9.4.575.
Buffered cephalothin, cefamandole, and cephapirin were compared with respect to their tendency to produce phlebitis. Two grams of each agent was administered every 6 h for 4 days to 12 healthy volunteers in a double-blind crossover fashion. Approximately 50% of intravenous sites developed mild (grade 1) phlebitis and 25% developed moderate (grade 2) phlebitis. The frequency of grade 1 inflammation did not differ significantly among the three cephalosporins. The proportion of individuals eventually exhibiting grade 2 phelebitis was highest with cefamandole, lowest with cephalothin (P = 0.07), and intermediate with cephapirin; however, cephapirin required a substantially greater number of doses to produce grade 2 phelebitis than did the other two drugs. These findings, together with the results of other reports, suggest that interpretation of the phlebitogenic potential of these antibiotics must be made with caution.
对头孢噻吩、头孢孟多和头孢匹林产生静脉炎的倾向进行了比较。以双盲交叉方式，每6小时给12名健康志愿者服用2克每种药物，持续4天。大约50%的静脉注射部位出现轻度（1级）静脉炎，25%出现中度（2级）静脉炎。三种头孢菌素之间1级炎症的发生率没有显著差异。最终出现2级静脉炎的个体比例，头孢孟多最高，头孢噻吩最低（P = 0.07），头孢匹林居中；然而，与其他两种药物相比，头孢匹林产生2级静脉炎所需的剂量要多得多。这些发现，连同其他报告的结果表明，对这些抗生素致静脉炎潜力的解释必须谨慎。
