Saji S, Sugiyama Y, Miya K, Oshita H, Yokoyama Y, Yamamoto S, Takekoshi T, Sakata K
Nihon Geka Gakkai Zasshi. 1983 Mar;84(3):179-85.
Immunologic merit and demerit of splenectomy were studied, using experimental model in rat.
SD rat. Tumor: Metastasizing Rat's Mammary Tumor No. 1 (MRMT-1) originally induced by 3-MC administration to SD rat. Experimental study: Splenectomy was done on day before and after subcutaneous inoculation of 200mg of MRMT-1 at the back of 4 week-old female SD rats. Tumor growth following splenectomy and immunological competency of rat's peripheral lymphocytes, spleen cells and thymus cells was investigated and following results were obtained. When splenectomy was done pre-operatively or on the 2nd or 14th day after tumor inoculation, subsequent tumor growth was inhibited, however, when it was done on the 7th day after the inoculation, tumor enhancement and shortening of survival period were observed. When it was done on the 21st day, tumor growth was almost the same as in the rats without splenectomy. The results of cpm values and SI ratio of PHA-induced blastogenesis, and NK-activity indicated that immunological competency of spleen cells of tumor bearers was reduced during the early tumor-bearing period and the late tumor bearing period, while it was increased in the middle tumor bearing period. Tumor growth following splenectomy was considered to be controlled by immunological competency of spleen cells. Thus, it may not be unreasonable that tumor growth is inhibited on some occasions and it is facilitated on other occasions after splenectomy.
使用大鼠实验模型研究了脾切除术的免疫优缺点。
SD大鼠。肿瘤：最初通过对SD大鼠施用3 - 甲基胆蒽诱导的转移性大鼠乳腺癌1号（MRMT - 1）。实验研究：在4周龄雌性SD大鼠背部皮下接种200mg MRMT - 1的前后一天进行脾切除术。研究了脾切除术后肿瘤的生长情况以及大鼠外周淋巴细胞、脾细胞和胸腺细胞的免疫能力，并获得了以下结果。当在术前或肿瘤接种后第2天或第14天进行脾切除术时，随后的肿瘤生长受到抑制，然而，当在接种后第7天进行时，观察到肿瘤增大和生存期缩短。当在第21天进行时，肿瘤生长与未进行脾切除术的大鼠几乎相同。PHA诱导的细胞增殖反应的cpm值和SI比值以及NK活性的结果表明，荷瘤大鼠脾细胞的免疫能力在荷瘤早期和晚期降低，而在荷瘤中期升高。脾切除术后的肿瘤生长被认为受脾细胞免疫能力的控制。因此，脾切除术后在某些情况下肿瘤生长受到抑制而在其他情况下肿瘤生长被促进可能并非不合理。
