Takekoshi T, Sakata K, Kunieda T, Saji S, Tanemura H, Yamamoto S
Oncology. 1984;41(4):245-51. doi: 10.1159/000225832.
5-week-old syngeneic female SD rats were inoculated subcutaneously at the dorsal flank with 200 mg of a metastasizing rat's mammary tumor, MRMT-1. A significantly higher incidence of lung metastasis was observed in the cases in which tumor excision on day 14 was accompanied by 30 min laparotomy than in the cases of simple tumor excision. PHA lymphoblastogenesis on day 17 was significantly lower in the cases of tumor excision plus laparotomy on day 14 than in the cases of simple tumor excision. Winn's assay using splenocytes revealed a postoperative enhanced suppressor activity in the cases undergoing laparotomy stress. Possible participation of the raised suppressor activity to facilitation of metastasis was discussed.
将5周龄的同基因雌性SD大鼠在背部侧腹皮下接种200毫克转移性大鼠乳腺肿瘤MRMT-1。与单纯肿瘤切除的情况相比，在第14天肿瘤切除同时进行30分钟剖腹术的病例中，观察到肺转移的发生率显著更高。在第14天进行肿瘤切除加剖腹术的病例中，第17天的PHA淋巴细胞生成明显低于单纯肿瘤切除的病例。使用脾细胞进行的温氏试验显示，接受剖腹术应激的病例术后抑制活性增强。讨论了升高的抑制活性可能参与促进转移的情况。
