药物对大鼠肛尾肌去甲肾上腺素蓄积及自发释放的影响。
Effects of drugs on the accumulation and spontaneous release of noradrenaline in the rat anococcygeus muscle.
作者信息
Doggrell S A, Woodruff G N
出版信息
Br J Pharmacol. 1978 Jul;63(3):465-70. doi: 10.1111/j.1476-5381.1978.tb07798.x.
Abstract
1 The ability of drugs to inhibit noradrenaline accumulation and to release noradrenaline was studied in the isolated anococcygeus muscle of the rat. 2 Noradrenaline, tyramine, 2-amino,6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN), 2-amino,6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene (dimethyl ADTN), and 5-hydroxytryptamine were all potent inhibitors of noradrenaline accumulation and potent releasers of noradrenaline. ADTN was accumulated by the rat isolated anococcygeus muscle. 3 Amphetamine and desipramine were potent inhibitors of noradrenaline accumulation but poor releasers of noradrenaline. 4 Methoxamine, oxymetazoline, acetylcholine, and angiotensin were poor inhibitors of noradrenaline accumulation and did not release noradrenaline. 5 The mechanism of action of these drugs is discussed.
摘要
- 在大鼠离体尾骨肌中研究了药物抑制去甲肾上腺素蓄积及释放去甲肾上腺素的能力。2. 去甲肾上腺素、酪胺、2-氨基-6,7-二羟基-1,2,3,4-四氢萘（ADTN）、2-氨基-6,7-二甲氧基-1,2,3,4-四氢萘（二甲基ADTN）和5-羟色胺均为去甲肾上腺素蓄积的强效抑制剂及去甲肾上腺素的强效释放剂。ADTN可被大鼠离体尾骨肌蓄积。3. 苯丙胺和地昔帕明是去甲肾上腺素蓄积的强效抑制剂，但却是去甲肾上腺素的低效释放剂。4. 甲氧明、羟甲唑啉、乙酰胆碱和血管紧张素是去甲肾上腺素蓄积的低效抑制剂，且不释放去甲肾上腺素。5. 讨论了这些药物的作用机制。
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