Blom H, Elstig H, Helander H F
Scand J Gastroenterol. 1983 Oct;18(7):859-64. doi: 10.3109/00365528309182106.
Parietal cell regeneration in cauterized gastric wounds was studied in rats after antrectomy (Billroth I), pyloroplasty, and truncal vagotomy with pyloroplasty. Six to eight animals in each group were killed 90 or 130 days after operation, and in each rat stereological data were obtained from electron micrographs of 15 to 20 parietal cells from the wound area, from the normal mucosa beside the wounds, and from the mucosa in unoperated controls. Antrectomy reduced parietal cell size and mucosal thickness in normal mucosa and retarded parietal cell maturation and reduced mucosal thickness in the healing wounds. Pyloroplasty slightly reduced parietal cell size in normal mucosa and retarded maturation of the parietal cells in the wounds. If truncal vagotomy was added, the reduction in parietal cell size induced by the pyloroplasty was prevented in normal mucosa.
在大鼠中，研究了胃窦切除术（毕罗一式）、幽门成形术以及迷走神经干切断术加幽门成形术后，烧灼性胃伤口中壁细胞的再生情况。每组6至8只动物在术后90天或130天处死，从伤口区域、伤口旁正常黏膜以及未手术对照的黏膜中选取15至20个壁细胞的电子显微照片，获取每只大鼠的体视学数据。胃窦切除术减小了正常黏膜中壁细胞的大小和黏膜厚度，延缓了愈合伤口中壁细胞的成熟，并减小了黏膜厚度。幽门成形术略微减小了正常黏膜中壁细胞的大小，延缓了伤口中壁细胞的成熟。如果加上迷走神经干切断术，幽门成形术诱导的正常黏膜中壁细胞大小的减小则可得到预防。
