Quinn P A, Rubin S, Nocilla D M, Read S E, Chipman M
Yale J Biol Med. 1983 Sep-Dec;56(5-6):565-72.
Since up to 80 percent of pregnant women and 30 percent of neonates may be colonized with genital mycoplasmas, it is difficult to determine whether true infection occurs. The antibody responses to eight serotypes of U. urealyticum were assessed in mothers and infants in 21 cases of neonatal respiratory disease (RD) and 24 normal cases. Among the normal population of mothers and infants, a titer of greater than or equal to 1:32 occurred in 0.25 percent (1/394). In mother-infant paired titers, a fourfold difference occurred in 2.6 percent (5/192). Among 54 RD neonates, 55.6 percent had a titer of greater than or equal to 1:32 compared to only 4.2 percent of normal neonates (p less than .001). Fourfold elevations in antibody titers of greater than 1:32 were observed in the neonate in 52.4 percent of RD cases compared to 0 percent of 24 normal pairs (p less than .001) and in 28.6 percent of mothers of RD neonates compared to 0 percent in normal cases (p = .013). We observed that 43.3 percent of RD neonates with titers greater than or equal to 1:32 died compared to 16.6 percent of RD neonates exhibiting no elevation of antibody response over the maternal level. Among the six who died, 66.7 percent of neonates and 16.7 percent of their mothers had elevated titers, compared to 33.3 percent of 15 surviving infants and 40.0 percent of their mothers. These elevated antibody responses strongly support the concept that U. urealyticum causes infection in the perinatal period in association with neonatal respiratory disease. Since the elevation in titers was detected close to delivery in many cases, the infection may occur in utero.
由于高达80%的孕妇和30%的新生儿可能被生殖支原体定植，因此很难确定是否发生了真正的感染。对21例新生儿呼吸道疾病（RD）病例和24例正常病例的母婴进行了针对解脲脲原体8种血清型的抗体反应评估。在正常母婴群体中，滴度大于或等于1:32的情况占0.25%（1/394）。在母婴配对滴度中，四倍差异的情况占2.6%（5/192）。在54例RD新生儿中，55.6%的滴度大于或等于1:32，而正常新生儿中这一比例仅为4.2%（p<0.001）。与24对正常配对中0%的情况相比，RD病例中52.4%的新生儿抗体滴度升高至大于1:32的四倍（p<0.001）；与正常病例中0%的情况相比，RD新生儿母亲中28.6%的抗体滴度升高（p=0.013）。我们观察到，抗体滴度大于或等于1:32的RD新生儿中有43.3%死亡，而抗体反应未超过母亲水平的RD新生儿中有16.6%死亡。在死亡的6例中，66.7%的新生儿及其母亲中有16.7%的滴度升高，而在15例存活婴儿及其母亲中，这一比例分别为33.3%和40.0%。这些升高的抗体反应有力地支持了解脲脲原体在围产期与新生儿呼吸道疾病相关联导致感染的概念。由于在许多情况下，滴度升高是在临近分娩时检测到的，因此感染可能发生在子宫内。
