Gomita Y, Kataoka Y, Ichimaru Y, Ueki S
Life Sci. 1983 Feb 28;32(9):941-7. doi: 10.1016/0024-3205(83)90923-2.
Methamphetamine induced mortality in physically stressed and non-physically stressed mice was investigated by employing a communication box in which shocked mice communicated their distress to unshocked mice in neighboring boxes. Intraperitoneal administration of methamphetamine 30 mg/kg caused greater mortality in both the shocked "sender" mice and the unshocked "responder" mice than in control when maintained at 27 +/- 1 degree C. Forty-eight hours after injection, the "sender", "responder" and control mice showed mortality of 80, 60 and 10%, respectively. This result indicates that the mortality of methamphetamine may be potentiated not only by physical stress but also by non-physical stress.
通过使用一个通讯箱来研究甲基苯丙胺在身体应激和非身体应激小鼠中诱导的死亡率，在该通讯箱中，受电击的小鼠将其痛苦传递给相邻箱子中未受电击的小鼠。当维持在27±1摄氏度时，腹腔注射30mg/kg甲基苯丙胺导致受电击的“发送者”小鼠和未受电击的“反应者”小鼠的死亡率均高于对照组。注射后48小时，“发送者”、“反应者”和对照小鼠的死亡率分别为80%、60%和10%。这一结果表明，甲基苯丙胺的死亡率不仅可能因身体应激而增强，也可能因非身体应激而增强。
