3,2'-二甲基-4-氨基联苯诱导仓鼠胆囊致癌作用及炔雌醇的影响
3,2'-Dimethyl-4-aminobiphenyl-induced gallbladder carcinogenesis and effects of ethinyl estradiol in hamsters.
作者信息
Hasegawa R, Ogawa K, Takaba K, Shirai T, Ito N
机构信息
First Department of Pathology, Nagoya City University Medical School.
出版信息
Jpn J Cancer Res. 1992 Dec;83(12):1286-92. doi: 10.1111/j.1349-7006.1992.tb02760.x.
The effects of ethinyl estradiol (EE) on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced carcinogenesis were examined in Syrian golden hamsters. DMAB was subcutaneously injected in corn oil at a concentration of 100 mg/kg once a week for 20 weeks and EE was administered in the diet at a dose of 0.75 ppm throughout the experiment. Some animals were killed at week 20 and all surviving ones were killed at week 50. Gallbladder tumors (adenomas and carcinomas) were induced in 6 of 15 hamsters (40%) in the DMAB + EE group and 5 of 14 (36%) in the DMAB alone group in males, and in 6 of 13 (46%) in the DMAB + EE group and 1 of 8 (13%) in the DMAB alone group in females at week 50. A clearer enhancing effect of EE on DMAB gallbladder carcinogenesis was observed for tumor multiplicity (No./animal) for both sexes; from 0.36 to 0.67 in males and from 0.14 to 0.62 in females. Thus, DMAB was demonstrated to be carcinogenic in the gallbladder of hamsters and EE enhanced this DMAB-induced gallbladder tumorigenesis.
在叙利亚金仓鼠中研究了乙炔雌二醇（EE）对3,2'-二甲基-4-氨基联苯（DMAB）诱导的致癌作用。DMAB以100 mg/kg的浓度溶于玉米油中，每周皮下注射一次，共注射20周，在整个实验过程中，EE以0.75 ppm的剂量添加到饲料中。一些动物在第20周处死，所有存活的动物在第50周处死。在第50周时，雄性DMAB + EE组15只仓鼠中有6只（40%）诱发胆囊肿瘤（腺瘤和癌），单独使用DMAB组14只中有5只（36%）；雌性DMAB + EE组13只中有6只（46%），单独使用DMAB组8只中有1只（13%）。对于两性的肿瘤 multiplicity（每只动物的肿瘤数量），观察到EE对DMAB胆囊致癌作用有更明显的增强作用；雄性从0.36增加到0.67，雌性从0.14增加到0.62。因此，证明DMAB对仓鼠胆囊具有致癌性，EE增强了这种DMAB诱导的胆囊肿瘤发生。
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