Naumova E S, Vorob'eva L I
Mikrobiologiia. 1983 Jan-Feb;52(1):64-7.
Transport of 14C-biotin was studied in cells of different biotin-prototrophous yeast and mold fungal strains. An inverse correlation was established between the capability of the fungi to synthesize biotin and the exogenous vitamin transport: 14C-biotin did not penetrate into the cells of strains which excreted great quantities of the vitamin. It is likely that a higher level of biotin synthesis in certain fungi is caused by a peculiar transport system, which results in a one-way permeability of their cell membrane for biotin. Biotin is eliminated from the cell and cannot repress its own synthesis. Active transport of biotin in the studied prototrophous organisms occurs against a concentration gradient and does not depend on the presence of glucose in the medium. There are apparently other energy sources for this process.
在不同生物素原养型酵母和霉菌真菌菌株的细胞中研究了¹⁴C-生物素的转运。已确定真菌合成生物素的能力与外源维生素转运之间呈负相关：¹⁴C-生物素不会渗透到分泌大量该维生素的菌株细胞中。某些真菌中生物素合成水平较高可能是由一种特殊的转运系统引起的，该系统导致其细胞膜对生物素具有单向通透性。生物素从细胞中排出，无法抑制其自身的合成。在所研究的原养型生物中，生物素的主动转运是逆浓度梯度进行的，并且不依赖于培养基中葡萄糖的存在。这个过程显然还有其他能量来源。
