Shchelokova E V, Vorob'eva L I
Prikl Biokhim Mikrobiol. 1982 Sep-Oct;18(5):630-5.
The capability of 26 collection micromycete strains to synthesize biotin and transform destiobiotin was investigated. Destiobiotin stimulated the biotin formation by the strains of the Aspergillus genus (except A. sclerotiorum synthesizing vitamin traces), the Fusarium genus, the Rhizopus genus (except Rh. nigricans), as well as Thighemella hyalospora and Sporotrichum sulfurescens. Among the strains tested Rhizopus delemar 1428 synthesized maximum quantities of biotin (over 300 micrograms/1). The biotin synthesis by this strain increased drastically when the fungal growth was terminated, about 90% of biotin being released into the medium. The rate of biotin synthesis and excretion grew significantly when the major portion of glucose was consumed and pH of the medium increased (to 8.0-8.2).
研究了26种集落微真菌菌株合成生物素和转化脱硫生物素的能力。脱硫生物素刺激了曲霉属（除合成微量维生素的菌核曲霉外）、镰刀菌属、根霉属（除黑根霉外）以及透明丝孢酵母和硫磺色孢丝菌的菌株形成生物素。在所测试的菌株中，德氏根霉1428合成的生物素量最大（超过300微克/1）。当真菌生长终止时，该菌株的生物素合成急剧增加，约90%的生物素释放到培养基中。当大部分葡萄糖被消耗且培养基pH值升高（至8.0 - 8.2）时，生物素的合成和排泄速率显著增加。
