对口服脂质体相关变形链球菌可溶性细胞壁抗原的局部和全身免疫反应。
Local and systemic immune response to orally administered liposome-associated soluble S. mutans cell wall antigens.
作者信息
Wachsmann D, Klein J P, Schöller M, Frank R M
出版信息
Immunology. 1985 Jan;54(1):189-93.
Abstract
The aim of the present study was to develop an immunization procedure which preferentially stimulated the IgA system of rats, with release of IgA in secretions. Rats immunized by intragastric route with liposome-associated soluble antigen extracted from Streptococcus mutans cell wall, showed a significantly higher IgA (and IgG) response than did rats injected with the soluble antigen alone. In saliva, maximal antibody titres were obtained 11 days after the beginning of intubations for IgA, and 16 days for IgG. After a booster immunization, the secondary response occurred very quickly in saliva and, like the primary response, it was almost exclusively of the IgA class. This demonstrates, on one hand the existence of immunological memory in the IgA system and, on the other, the efficiency of liposomes as insoluble adjuvants in eliciting an immunological response.
摘要
本研究的目的是开发一种免疫程序，该程序优先刺激大鼠的IgA系统，并使分泌物中释放IgA。经胃内途径用从变形链球菌细胞壁提取的脂质体相关可溶性抗原免疫的大鼠，其IgA（和IgG）反应明显高于仅注射可溶性抗原的大鼠。在唾液中，插管开始后11天获得IgA的最大抗体滴度，16天获得IgG的最大抗体滴度。加强免疫后，唾液中的二次反应非常迅速，并且与初次反应一样，几乎完全是IgA类。这一方面证明了IgA系统中存在免疫记忆，另一方面证明了脂质体作为不溶性佐剂引发免疫反应的效率。
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