正常及新生期胸腺切除大鼠中含免疫球蛋白细胞的分布
Distribution of immunoglobulin-containing cells in normal and neonatally thymectomized rats.
作者信息
Ebersole J L, Taubman M A, Smith D J
出版信息
Infect Immun. 1983 Nov;42(2):668-74. doi: 10.1128/iai.42.2.668-674.1983.
The distribution of immunoglobulin-containing cells (ICC) of the immunoglobulin A (IgA), IgG, and IgM isotypes was examined in various lymphoid and secretory tissues of rats. The effect of neonatal thymectomy of rats on T cells, B cells, and ICC in these tissues was determined by immunofluorescence. The results showed that although T cells were severely depleted in both lymphoid and secretory tissues of the thymectomized (Tx) rats, Tx and normal rats showed comparable numbers of B cells staining for IgA, IgG, and IgM. After neonatal thymectomy, IgA ICC in both lymphoid and secretory tissues were significantly decreased. However, the Tx rats exhibited a compensatory increase in IgM ICC in the identical tissues. Local injection of normal and Tx rats with Streptococcus mutans 6715 resulted in an increase in all isotypes of ICC in the secretory tissues. Although the primary increase in normal rats was due to IgA ICC, Tx rats exhibited the greatest change in the number of IgM ICC.
对大鼠各种淋巴组织和分泌组织中免疫球蛋白A（IgA）、IgG和IgM同种型的含免疫球蛋白细胞（ICC）分布进行了检测。通过免疫荧光法测定了新生大鼠胸腺切除对这些组织中T细胞、B细胞和ICC的影响。结果显示，虽然胸腺切除（Tx）大鼠的淋巴组织和分泌组织中的T细胞严重耗竭，但Tx大鼠和正常大鼠中染色显示IgA、IgG和IgM的B细胞数量相当。新生大鼠胸腺切除后，淋巴组织和分泌组织中的IgA ICC均显著减少。然而，Tx大鼠在相同组织中的IgM ICC出现代偿性增加。对正常大鼠和Tx大鼠局部注射变形链球菌6715导致分泌组织中所有同种型的ICC增加。虽然正常大鼠中ICC的最初增加是由于IgA ICC，但Tx大鼠的IgM ICC数量变化最大。
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