Dhavare B S, Nandal N V, Balsara J J, Chandorkar A G
Indian J Physiol Pharmacol. 1983 Jan-Mar;27(1):19-24.
Pretreatment with L-tryptophan, a precursor of 5-HT, was found to decrease the intensity of stereotyped behaviour induced by amantadine, while methysergide, a 5-HT antagonist, was found to increase the intensity of amantadine-induced stereotypy. These results suggest that the intensity of amantadine-induced stereotypy depends on the balance between central dopamine and 5-HT systems and that the central 5-HT systems may have an opposing, tonic effect upon central dopamine systems involved in the mediation of stereotypy. In contrast to L-tryptophan, however, pretreatment with quipazine, a 5-HT agonist, and clomipramine, a selective 5-HT neuronal reuptake blocker, was found to potentiate the stereotyped behaviour induced by amantadine.
5-羟色胺（5-HT）的前体L-色氨酸预处理可降低金刚烷胺诱导的刻板行为强度，而5-HT拮抗剂甲基麦角新碱则会增强金刚烷胺诱导的刻板行为强度。这些结果表明，金刚烷胺诱导的刻板行为强度取决于中枢多巴胺系统和5-HT系统之间的平衡，并且中枢5-HT系统可能对参与刻板行为介导的中枢多巴胺系统具有相反的、紧张性作用。然而，与L-色氨酸相反，5-HT激动剂喹哌嗪和选择性5-HT神经元再摄取阻滞剂氯米帕明预处理后，会增强金刚烷胺诱导的刻板行为。
