de Jongh G J, Spruit D
Contact Dermatitis. 1978 Jun;4(3):149-56. doi: 10.1111/j.1600-0536.1978.tb03762.x.
The nickel concentrations in urine and other data of a very hypersensitive female patient have been followed during two periods exceeding 30 days each. Only a limited degree of correlation was found between the course of the nickel concentration in urine and the clinical activity of the dermatitis. In order to better evaluate the measure of the correlation and the influence of some other factors upon the activity of the dermatitis, a pathway analysis scheme has been constructed. Consideration of this scheme reveals the need for more extensive data regarding the nickel ion climate in the body.
在两个均超过30天的时间段内，对一名超敏女性患者尿液中的镍浓度及其他数据进行了跟踪。尿液中镍浓度的变化过程与皮炎的临床活动之间仅发现了有限程度的相关性。为了更好地评估相关性的程度以及其他一些因素对皮炎活动的影响，构建了一个路径分析方案。对该方案的考量表明，需要关于体内镍离子环境的更广泛数据。
