冈比亚农村母亲母乳保护因子浓度变化的决定因素。
Determinants of variations in breast milk protective factor concentrations of rural Gambian mothers.
作者信息
Prentice A, Prentice A M, Cole T J, Whitehead R G
出版信息
Arch Dis Child. 1983 Jul;58(7):518-22. doi: 10.1136/adc.58.7.518.
Abstract
The concentrations of 7 immunoproteins (IgA, IgG, IgM, the complement components C3 and C4, lactoferrin, and lysozyme) in the breast milk of 152 rural west African women were measured as part of a semilongitudinal study to assess their importance in infant health. Each mother maintained a characteristic level of production of immunoproteins relative to other mothers, and the concentration of each immunoprotein within each woman was correlated positively with the others. Parity was the major determinant of ranking and mothers of parity 1 and 2 produced the highest concentrations of immunoproteins. Except for lysozyme, infants' intake of these protective factors decreased in early lactation, but infants aged 1-2 years still received substantial amounts. The daily intakes by Gambian infants were similar to or higher than those of infants in Cambridge, United Kingdom. A marked seasonal increase in infant morbidity was not accompanied by an increase in the concentrations of protective factors in mothers' milk.
摘要
作为一项半纵向研究的一部分，对152名西非农村妇女母乳中7种免疫蛋白（免疫球蛋白A、免疫球蛋白G、免疫球蛋白M、补体成分C3和C4、乳铁蛋白和溶菌酶）的浓度进行了测量，以评估它们在婴儿健康中的重要性。相对于其他母亲，每位母亲的免疫蛋白产生水平都保持着各自的特点，并且每位女性体内每种免疫蛋白的浓度与其他免疫蛋白呈正相关。产次是排名的主要决定因素，初产和经产2次的母亲产生的免疫蛋白浓度最高。除溶菌酶外，这些保护因子在哺乳早期婴儿的摄入量会下降，但1至2岁的婴儿仍能获得大量摄入。冈比亚婴儿的每日摄入量与英国剑桥的婴儿相似或更高。婴儿发病率的显著季节性增加并未伴随着母乳中保护因子浓度的增加。
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