Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
J Mother Child. 2021 Jan 29;24(3):8-15. doi: 10.34763/jmotherandchild.20202403.2032.d-20-00001. eCollection 2020 Sep 1.
The study investigated the concentration of IgA, IgM and IgG in colostrum, transitional and mature milk and the effect of parity, age, BMI and family income on secreted immunoglobulin contents of human milk.
Sequential samples of colostrum, transitional and mature milk were collected from 38 women. Enzymelinked immunosorbent assay was used to analyse the immunoglobulin concentrations.
The study revealed that IgA was the dominant immunoglobulin and mean concentration in colostrum, transitional and mature milk was 5.92 ± 1.50 g/L, 3.85 ± 0.64 g/L and 3.72 ± 0.68 g/L, respectively. Both IgA and IgM levels of colostrum decreased significantly in both transitional ( = 0.000) and mature milk ( = 0.000), while the concentration of IgG rises significantly in them (colostrum . transitional milk, = 0.000; and colostrum . mature milk = 0.011). While maternal age, BMI and family income had no significant influence on the immunoglobulin levels at different stages of lactation, parity showed significant influence on IgG ( = 0.03) and IgM ( = 0.05) levels of transitional milk and IgA level of colostrum ( = 0.05).
The findings suggest that immunoglobulin composition in breast milk is strongly associated with stage of lactation and is likely to be more susceptible to parity than BMI and socioeconomic characteristics.
本研究调查了初乳、过渡乳和成熟乳中 IgA、IgM 和 IgG 的浓度，以及产次、年龄、BMI 和家庭收入对人乳分泌免疫球蛋白含量的影响。
从 38 名女性中连续采集初乳、过渡乳和成熟乳样本。采用酶联免疫吸附试验分析免疫球蛋白浓度。
研究表明，IgA 是主要的免疫球蛋白，初乳、过渡乳和成熟乳中的平均浓度分别为 5.92±1.50 g/L、3.85±0.64 g/L 和 3.72±0.68 g/L。初乳和过渡乳中的 IgA 和 IgM 水平均显著降低（=0.000），而 IgG 浓度显著升高（初乳-过渡乳，=0.000；初乳-成熟乳，=0.011）。然而，母亲年龄、BMI 和家庭收入对不同泌乳阶段的免疫球蛋白水平没有显著影响，产次对过渡乳中的 IgG（=0.03）和 IgM（=0.05）以及初乳中的 IgA 水平（=0.05）有显著影响。
研究结果表明，母乳中的免疫球蛋白组成与泌乳阶段密切相关，而且可能比 BMI 和社会经济特征更容易受到产次的影响。
