Low-resolution autoradiography in rat brain after administering labelled CDP-choline.

14C-Methyl labelled cytidine diphosphate choline (CDP-choline, citicoline, Somazina) at a dose of 10 microCi has been administered orally to rats. Half of animals were sacrificed at 5 h, and other half at 24 h after administration. Autoradiography preparations of brain were isolated according to a relevant method for optical microscopy examination. Extra- and intracellular distribution of the drug after different unlabelling times has been studied. The intracellular radioactivity was checked 24 h after administration.