Romero A, Serratosa J, Sacristán A, Ortiz J A
Arzneimittelforschung. 1983;33(7A):1054-6.
14C-Methyl labelled cytidine diphosphate choline (CDP-choline, citicoline, Somazina) at a dose of 10 microCi has been administered orally to rats. Half of animals were sacrificed at 5 h, and other half at 24 h after administration. Autoradiography preparations of brain were isolated according to a relevant method for optical microscopy examination. Extra- and intracellular distribution of the drug after different unlabelling times has been studied. The intracellular radioactivity was checked 24 h after administration.
已给大鼠口服剂量为10微居里的14C-甲基标记的胞苷二磷酸胆碱（CDP-胆碱、胞磷胆碱、索马西纳）。给药后5小时处死一半动物，另一半在24小时后处死。根据用于光学显微镜检查的相关方法分离脑的放射自显影片制剂。研究了不同去标记时间后药物在细胞外和细胞内的分布。给药24小时后检查细胞内放射性。
