放射性标记的胞苷二磷酸胆碱给药24小时后小鼠脑内的高分辨率放射自显影。
High-resolution autoradiography in mouse brain 24 h after radiolabelled CDP-choline administration.
作者信息
Romero A, Serratosa J, Sacristán A, Ortiz J A
出版信息
Arzneimittelforschung. 1983;33(7A):1056-8.
A group of mice was given 10 microCi/animal of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) (methyl 14C). Animals were sacrificed 24 h after administration and their brains isolated for electron microscopy and autoradiography. The main purpose of the present study was to examine the intracellular distribution of the drug and its possible specificity site in specific organelles and cellular structures. While a large quantity of radioactivity appeared in cellular membranes, no selectivity was in its distribution thus being detected in several cellular organelles and free hyaloplasm.
给一组小鼠每只注射10微居里的胞苷二磷酸胆碱（CDP - 胆碱、胞磷胆碱、索马西纳）（甲基 - 14C）。给药24小时后处死动物，分离其大脑用于电子显微镜检查和放射自显影。本研究的主要目的是检查药物在细胞内的分布及其在特定细胞器和细胞结构中的可能特异性位点。虽然在细胞膜中出现了大量放射性，但在其分布上没有检测到选择性，因此在几个细胞器和游离细胞质中都有发现。
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