High-resolution autoradiography in mouse brain and cerebellum 10 days after radiolabelled CDP-choline administration.

A dose of 5 microCi of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) (methyl 14C) was administered to mice. Animals were sacrificed 10 days after administration and their brain and cerebellum isolated for autoradiography and electron microscopy. Sections were prepared in such a manner that a general topographic assignment of radioactivity distribution to different layers and brain structures could be made. Regarding the intracellular distribution of the different cellular types observed, Purkinje's cells exhibited in a density of focus emission higher than the others.