Cunningham H M, Lawrence G A, Tryphonas L
J Toxicol Environ Health. 1977 May;2(5):1161-71. doi: 10.1080/15287397709529514.
Four experiments were conducted using weanling Wistar rats to determine whether chlorinated cake flour or its constituents were toxic. Levels of 0.2 and 1.0% chlorine added to unbleached cake flour significantly (p less than 0.01) reduced growth rate by 20.7 and 85.2% and increased liver weight relative to body weight by 16.7 and 25.3%, respectively. Lipids extracted from flour chlorinated at the same levels had similar effects. Rat chow diets containing 0.2 and 0.6% chlorine in the form of chlorinated wheat gluten reduced growth rate and increased liver weight as a percentage of body weight. A rat chow diet containing 0.2% chlorine as chlorinated flour lipids increased absolute liver weight by 40%, kidney by 20%, and heart by 10% compared to pair-fed controls.
进行了四项实验，使用断乳的Wistar大鼠来确定氯化蛋糕粉或其成分是否有毒。向未漂白的蛋糕粉中添加0.2%和1.0%的氯，显著（p小于0.01）使生长速率分别降低了20.7%和85.2%，并使肝脏重量相对于体重分别增加了16.7%和25.3%。从相同氯含量水平的氯化面粉中提取的脂质具有类似的效果。含有0.2%和0.6%以氯化小麦面筋形式存在的氯的大鼠饲料降低了生长速率，并增加了肝脏重量占体重的百分比。与配对喂养的对照组相比，含有0.2%以氯化面粉脂质形式存在的氯的大鼠饲料使肝脏绝对重量增加了40%，肾脏增加了20%，心脏增加了10%。
