Sonnenberg H, Milojevic S, Chong C K, Veress A T
Hypertension. 1983 Sep-Oct;5(5):672-5. doi: 10.1161/01.hyp.5.5.672.
We recently discovered a potent natriuretic factor in cardiac atrial tissue. The present experiments were designed to determine whether hypertension was associated with altered tissue content of this atrial natriuretic factor. Extracts were prepared using fresh atria from spontaneously hypertensive rats of the Okamoto strain and from their Wistar-Kyoto controls. Two groups of anesthetized, normovolemic rats (Sprague-Dawley) were used to measure the renal natriuretic and chloriuretic effect of each type of extract. Results indicate that atrial content of natriuretic factor is reduced in hypertensive rats compared to control animals. We speculate that chronic release of the factor could have depleted atrial stores, and that increased blood levels of atrial natriuretic factor may be involved in the generation and maintenance of hypertension in this model.
我们最近在心脏心房组织中发现了一种强效利钠因子。目前的实验旨在确定高血压是否与这种心房利钠因子的组织含量改变有关。使用冈本品系自发性高血压大鼠及其Wistar-Kyoto对照的新鲜心房制备提取物。两组麻醉的、血容量正常的大鼠（Sprague-Dawley）用于测量每种提取物的肾利钠和利氯作用。结果表明，与对照动物相比，高血压大鼠心房利钠因子的含量降低。我们推测，该因子的慢性释放可能耗尽了心房储存，并且心房利钠因子血水平升高可能参与了该模型中高血压的发生和维持。
