Nandy K, Lal H, Bennett M, Bennett D
Life Sci. 1983 Oct 10;33(15):1499-503. doi: 10.1016/0024-3205(83)90853-6.
Previous studies have indicated an increase in brain-reactive antibodies (BRA) in sera of aging mammals and an autoimmune disorder underlying senescence has been suggested. Since New Zealand Black (NZB) mice have a shorter lifespan and greater propensity for autoimmune diseases than C57BL/6 mice, various age groups from both strains of mice were investigated for simultaneous occurrence of BRA serum titer and deficits in learning. NZB mice exhibited a marked learning deficit as well as higher BRA levels at all ages. C57BL/6 mice showed increased BRA and a learning deficit only at advanced ages. The findings of "precocious" BRA titers along with marked learning deficits, both occurring at young ages in NZB mice and both similar to defects seen in the normal mice at senescence and in patients with senile-dementia, suggest that NZB mice may serve as a useful animal model of pre-senile dementia.
先前的研究表明，衰老哺乳动物血清中的脑反应性抗体（BRA）有所增加，有人提出衰老存在自身免疫性疾病。由于新西兰黑（NZB）小鼠的寿命比C57BL/6小鼠短，且患自身免疫性疾病的倾向更大，因此对这两种品系小鼠的不同年龄组进行了研究，以同时观察BRA血清滴度和学习缺陷情况。NZB小鼠在所有年龄段均表现出明显的学习缺陷以及较高的BRA水平。C57BL/6小鼠仅在老年时BRA水平升高且出现学习缺陷。NZB小鼠在年轻时就出现“早熟”的BRA滴度以及明显的学习缺陷，这两者与正常衰老小鼠和老年痴呆患者所见到的缺陷相似，这些发现表明NZB小鼠可能是早老性痴呆的有用动物模型。
