Lal H, Bennett M, Bennett D, Forster M J, Nandy K
Life Sci. 1986 Aug 11;39(6):507-12. doi: 10.1016/0024-3205(86)90506-0.
The extent to which immune processes contribute to senescence-related neurological/behavioral impairment was examined using an adoptive transfer procedure. C57BL/6 mice aged 22 to 24 months showed impaired ability for acquisition of an active avoidance response when compared with younger mice aged 3 months. An immunofluorescence assay of the sera of these mice indicated that only sera from the senescent mice reacted with brain antigen. When tested three months following irradiation and receipt of bone marrow/spleen cell suspensions from senescent mice, young mice showed senescence-like serum-brain reactivity and declines in their abilities to acquire learning. Young control mice receiving cell suspensions from age-matched donors showed no evidence of serum-brain reactivity or learning deficits, suggesting that impaired learning was related to acquisition of aged immunity and not a nonspecific effect of the transfer procedure. These findings indicate that immune processes may be involved in the etiology of senescence-related neurological/behavioral dysfunctions.
使用过继转移程序研究了免疫过程对衰老相关神经/行为损伤的影响程度。与3个月大的年轻小鼠相比，22至24个月大的C57BL/6小鼠获得主动回避反应的能力受损。对这些小鼠血清的免疫荧光分析表明，只有衰老小鼠的血清与脑抗原有反应。在接受衰老小鼠的骨髓/脾细胞悬液照射三个月后进行测试时，年轻小鼠表现出衰老样血清-脑反应性，其学习能力下降。接受年龄匹配供体细胞悬液的年轻对照小鼠没有血清-脑反应性或学习缺陷的迹象，这表明学习受损与获得衰老免疫有关，而不是转移程序的非特异性效应。这些发现表明，免疫过程可能参与了衰老相关神经/行为功能障碍的病因。
