Cardone G, Monteleone P, Cutillo G, Steardo L
Boll Soc Ital Biol Sper. 1983 Jul 30;59(7):921-7.
The validity of the dexamethasone ofe suppression test was evaluated for the differential diagnosis of major and minor depressive disorders. Thirty-eight out-patients (14 major depressed, 14 minor depressed and 10 normal controls) were studied. The Research Diagnostic Criteria of Spitzer et al. (1978) were used to classify these patients. Six out of the 14 major depressed patients had an abnormally high plasma cortisol at 4 p.m. and at 11.00 p.m. after midnight 2 mg-dexamethasone. None of the 14 minor depressed patients and none of the 10 controls had an abnormal response to dexamethasone. Based on these results, the dexamethasone suppression test has a sensitivity of 43%, a specificity of 100% and a high predictive value.
为评估地塞米松抑制试验在鉴别重度和轻度抑郁症中的有效性，对38名门诊患者（14名重度抑郁症患者、14名轻度抑郁症患者和10名正常对照者）进行了研究。采用斯皮策等人（1978年）的研究诊断标准对这些患者进行分类。14名重度抑郁症患者中有6名在午夜后服用2毫克地塞米松后，下午4点和晚上11点时血浆皮质醇异常升高。14名轻度抑郁症患者和10名对照者对地塞米松均无异常反应。基于这些结果，地塞米松抑制试验的敏感性为43%，特异性为100%，且具有较高的预测价值。
