Ellison G, Levy A, Lorant N
Pharmacol Biochem Behav. 1983;18 Suppl 1:565-70. doi: 10.1016/0091-3057(83)90237-x.
Rats with free access to water and 10% alcohol were raised in enriched, social colonies for prolonged periods of time. Then those animals which had developed extreme alcohol or water preferences were identified for further study. These selected animals were marked and returned to the colony. Both high and low alcohol consumers showed increased alcohol consumption just prior to feeding, but only the high consumers had a peak of alcohol consumption during the early morning hours. Compared to low consumers, high alcohol consumers ate less food, ran less in the activity wheel, spent more time in the burrows, and ranked low on several dominance measures. When access to alcohol was removed in the colony, these high alcohol consumers became more active but remained low in dominance. When tested in photocell cages, they showed a pattern of hyperactivity suggesting withdrawal effects. This sub-population of animals from rat colonies who voluntarily prefer alcohol to water represent a novel and social animal model of chronic alcohol consumption.
可自由获取水和10%酒精的大鼠在丰富的群居环境中饲养了很长一段时间。然后，识别出那些对酒精或水有极端偏好的动物进行进一步研究。这些被挑选出的动物做了标记后放回群落。高酒精摄入量和低酒精摄入量的大鼠在进食前酒精摄入量均增加，但只有高酒精摄入量的大鼠在清晨时段有酒精摄入量峰值。与低酒精摄入量的大鼠相比，高酒精摄入量的大鼠进食较少，在活动轮中跑动较少，在洞穴中停留时间更长，并且在几项优势度测量中排名较低。当群落中不再提供酒精时，这些高酒精摄入量的大鼠变得更加活跃，但优势度仍然较低。在光电管笼中进行测试时，它们表现出一种多动模式，表明有戒断效应。这群来自大鼠群落、自愿偏好酒精而非水的动物代表了一种新型的慢性酒精消费群居动物模型。
