Bartoshevich Iu E, Zaslavskaia P L, Beliaeva T V
Antibiotiki. 1983 Aug;28(8):563-6.
The nature of the fine structure of the spores of fusidic acid-producing organism changed with an increase in the antibiotic activity of its strains. Impairments in the structure of the cell coating were observed. The surface layers of the spore wall became labile, they were capable of separating, destructive impairment in the electron solid structures were detected in the spore cytoplasm, such impairments resulted in autolysis of extended areas. The lability of the surface layers of the spore wall promoted contacts between the spore cell coatings. The increased adhesive properties of the spore coatings resulted in formation of the spore "heads" typical of sporulation in highly active strains. The latter were characterized by a marked increase in the number of the spores filled with lipids and devoid of the main cell organelles and having a changed structure of the spore wall. This explained the marked decrease in the viability of the conidia of the highly active strains of the organism producing fusidic acid.
产生夫西地酸的生物体孢子的精细结构性质随其菌株抗生素活性的增加而改变。观察到细胞包膜结构受损。孢子壁的表层变得不稳定，它们能够分离，在孢子细胞质中检测到电子致密结构的破坏性损伤，这种损伤导致大片区域自溶。孢子壁表层的不稳定性促进了孢子细胞包膜之间的接触。孢子包膜增加的粘附特性导致在高活性菌株中形成典型的孢子“头”。后者的特征是充满脂质且缺乏主要细胞器且孢子壁结构发生变化的孢子数量显著增加。这解释了产生夫西地酸的生物体高活性菌株分生孢子活力的显著下降。
