Lee R J, Lomax P
Peptides. 1983 Nov-Dec;4(6):801-5. doi: 10.1016/0196-9781(83)90070-0.
Recent reports suggest that arginine vasopressin (AVP) may be an endogenous antipyretic peptide and a mediator of febrile convulsions [10,12]. The spontaneously seizing Mongolian gerbil was used to investigate the thermoregulatory, behavioral and seizure modulatory effects of AVP. Injection of AVP (1.0 and 5.0 micrograms IV and 0.01-1.0 mg/kg SC) caused dose-related falls in body temperature. Stereotypic scratching, terminated by a body shake, was observed after AVP (1.0-5.0 micrograms IV). However, such behavior was not observed after subcutaneous injection of AVP. AVP did not potentiate seizure induction in the gerbils but rather reduced the seizure incidence. The data demonstrate that AVP can reduce body temperature and cause specific behaviors, but it does not appear to play a role in the pathogenesis of seizures in the seizure sensitive strain of Mongolian gerbil.
最近的报告表明，精氨酸加压素（AVP）可能是一种内源性解热肽，也是热性惊厥的介质[10,12]。本研究使用自发惊厥的蒙古沙鼠来探究AVP对体温调节、行为及惊厥调节的影响。静脉注射AVP（1.0和5.0微克）以及皮下注射AVP（0.01 - 1.0毫克/千克）均导致体温呈剂量依赖性下降。静脉注射AVP（1.0 - 5.0微克）后，观察到出现刻板抓挠行为，随后伴有身体抖动。然而，皮下注射AVP后未观察到此类行为。AVP并未增强沙鼠的惊厥诱导，反而降低了惊厥发生率。数据表明，AVP可降低体温并引发特定行为，但在对惊厥敏感的蒙古沙鼠品系中，它似乎在癫痫发病机制中不起作用。
