Breitschwerdt E B, Ochoa R, Waltman C
J Am Vet Med Assoc. 1983 Jun 15;182(12):1348-53.
Three Basenji dogs with renal tubular dysfunction were studied. Hyposthenuria and diminished urine concentrating ability, indicative of nephrogenic diabetes insipidus, were documented. Metabolic acidosis, hyperchloremia, and reduction in glomerular filtration rate also were detected in all dogs. In addition, an exaggerated response to the adrenocorticotropin test and hyperaldosteronism, believed to be secondary to decreased effective circulating blood volume, were detected in all 3 dogs. Thyroxine values were decreased in all dogs and could be correlated with histopathologic changes of the thyroid gland in 2 dogs. Gastropathy and hypergastrinemia were identified in 2 dogs. Diffuse lymphocytic-plasmacytic enteritis was evident in 2 dogs. It was concluded that a urine concentrating defect that may be secondary to hypercortisolism exists in Basenji dogs with renal tubular dysfunction.
对三只患有肾小管功能障碍的巴仙吉犬进行了研究。记录到尿比重低和尿液浓缩能力下降，这表明存在肾性尿崩症。在所有犬只中还检测到代谢性酸中毒、高氯血症和肾小球滤过率降低。此外，在所有三只犬中均检测到对促肾上腺皮质激素试验的反应过度和醛固酮增多症，认为这是继发于有效循环血容量减少的结果。所有犬只的甲状腺素值均降低，并且在两只犬中与甲状腺的组织病理学变化相关。在两只犬中发现了胃病和高胃泌素血症。两只犬出现弥漫性淋巴细胞 - 浆细胞性肠炎。得出的结论是，患有肾小管功能障碍的巴仙吉犬存在可能继发于皮质醇增多症的尿液浓缩缺陷。
