Bovée K C, Joyce T, Blazer-Yost B, Goldschmidt M S, Segal S
J Am Vet Med Assoc. 1979 May 15;174(10):1094-9.
Ten adult dogs with multiple spontaneous defects of renal tubular reabsorption were studied. Clinical signs included polydipsia, polyuria, and glycosuria for 2 to 12 months. Eight of the dogs were Basenjis. Urinalyses revealed hyposthenuria, glycosuria, and amino aciduria in most dogs. Renal function was normal in 5 dogs and slightly reduced in the remainder. Moderate metabolic acidosis had developed in 3 dogs. Renal clearance studies revealed reduced tubular reabsorption of glucose, phosphate, sodium, potassium, and uric acid. Abnormal glucose tubular maximal curves were found. Results of oral glucose tolerance tests were normal. Two patterns of abnormal amino aciduria were evident: generalized amino aciduria and a pattern similar to that of cystinuria in dogs. Radiography of long bones and bone densitometry did not reveal any skeletal abnormalities. Five of the dogs died within 90 days of diagnosis; death was due to acute renal failure associated with profound dehydration, acidosis, and papillary necrosis. The other dogs remained stable without treatment after 18 months. Histopathology of kidneys did not reveal uniform abnormalities; some dogs had variable and nonspecific changes and others were normal. Electron microscopy did not reveal ultrastructural abnormalities in renal tubular cells. It was concluded that the syndrome in these dogs represents a new entity of renal disease in dogs, similar to idiopathic Fanconi syndrome in man.
对10只患有多种肾小管重吸收自发性缺陷的成年犬进行了研究。临床症状包括多饮、多尿和糖尿，持续2至12个月。其中8只犬为巴仙吉犬。大多数犬的尿液分析显示尿比重低、糖尿和氨基酸尿。5只犬的肾功能正常，其余犬的肾功能略有降低。3只犬出现了中度代谢性酸中毒。肾脏清除率研究显示，葡萄糖、磷酸盐、钠、钾和尿酸的肾小管重吸收减少。发现了异常的葡萄糖肾小管最大曲线。口服葡萄糖耐量试验结果正常。明显存在两种异常氨基酸尿模式：全身性氨基酸尿和一种与犬胱氨酸尿症相似的模式。长骨X线摄影和骨密度测定未发现任何骨骼异常。5只犬在诊断后90天内死亡；死亡原因是与严重脱水、酸中毒和乳头坏死相关的急性肾衰竭。其他犬在18个月后未经治疗仍保持稳定。肾脏组织病理学未发现一致的异常；一些犬有可变的非特异性变化，另一些犬则正常。电子显微镜检查未发现肾小管细胞的超微结构异常。得出的结论是，这些犬的综合征代表了犬类肾脏疾病的一种新实体，类似于人类的特发性范科尼综合征。
