Bovee K C, Joyce T, Reynolds R, Segal S
Science. 1978 Sep 22;201(4361):1129-31. doi: 10.1126/science.684432.
The renal defects resulting in a Fanconi syndrome were seen in eight Basenji dogs by measuring renal clearance and in vitro amino acid and sugar uptake and performing histopathologic evaluations. Renal tubular handling of glucose, phosphate, sodium, potassium, uric acid, and amino acids was abnormal, and in vitro uptake of labeled lysine, glycine, and alpha-methyl-D-glucoside by renal cortical slices was impaired. Histopathology was normal except for enlarged nuclei in some renal tubule cells. These Basenji dogs, which may be genetically affected, represent a likely model for idiopathic Fanconi syndrome in humans.
通过测量肾脏清除率、体外氨基酸和糖摄取以及进行组织病理学评估，在8只巴仙吉犬中发现了导致范科尼综合征的肾脏缺陷。肾小管对葡萄糖、磷酸盐、钠、钾、尿酸和氨基酸的处理异常，并且肾皮质切片对标记的赖氨酸、甘氨酸和α-甲基-D-葡萄糖苷的体外摄取受损。除了一些肾小管细胞的细胞核增大外，组织病理学检查结果正常。这些可能受到遗传影响的巴仙吉犬代表了人类特发性范科尼综合征的一种可能模型。
