Patel D M, Donovan E F, Keenan W J
Biol Neonate. 1983;43(3-4):146-51. doi: 10.1159/000241621.
57 newborn infants delivered by planned, repeat cesarian section were studied to determine the role of surfactant in transient neonatal respiratory distress. 22.8% of the newborn infants studied had transient tachypnea of the newborn. The mean amniotic fluid lecithin-sphingomyelin ratio (L/S) was 2.8 in normal infants and 2.6 in infants with transient tachypnea. The mean gastric aspirate L/S at the time of delivery was 3.0 in the normal infants and 2.7 in infants with transient tachypnea. There were no statistically significant differences in either amniotic fluid L/S or gastric aspirate L/S. Based on these results we speculate that, despite altered lung mechanics in neonates with transient tachypnea, lung maturity as determined by L/S ratio does not differ from that of normal neonates.
对57例经计划再次剖宫产分娩的新生儿进行了研究,以确定表面活性剂在新生儿短暂性呼吸窘迫中的作用。研究的新生儿中有22.8%发生了新生儿短暂性呼吸急促。正常婴儿羊水卵磷脂与鞘磷脂的平均比值(L/S)为2.8,有短暂性呼吸急促的婴儿为2.6。分娩时正常婴儿胃吸出物的平均L/S为3.0,有短暂性呼吸急促的婴儿为2.7。羊水L/S或胃吸出物L/S均无统计学显著差异。基于这些结果,我们推测,尽管有短暂性呼吸急促的新生儿肺力学发生了改变,但由L/S比值确定的肺成熟度与正常新生儿并无差异。