Saux M C, Mosser J, Pontagnier H, Leng B
Eur J Drug Metab Pharmacokinet. 1983;8(1):43-9. doi: 10.1007/BF03189580.
Pharmacokinetic parameters of doxycycline polyphosphate were studied in healthy volunteers after oral administration of a single 200 mg dose of this antibiotic with a breakfast containing or not 200 ml of whole milk. Ingestion of milk had only mild effect upon absorption parameters of doxycycline; only a moderate increase of the lag-time was significant. Elimination parameters of doxycycline were impaired by milk; a decrease of the terminal half-life from 28 h to 15 h, and apparent decrease of the enterohepatic circulation and an increase in total body clearance from 40 to 62 ml/min. were observed.
在健康志愿者口服单次200毫克剂量的多西环素多磷酸盐后，研究了其药代动力学参数。此次给药时早餐中含有或不含有200毫升全脂牛奶。摄入牛奶对多西环素的吸收参数仅有轻微影响；仅滞后时间有中度增加且具有显著性。牛奶会损害多西环素的消除参数；观察到终末半衰期从28小时降至15小时，肝肠循环明显减少，全身清除率从40毫升/分钟增至62毫升/分钟。
