Meyer F P, Specht H, Quednow B, Walther H
Institut für Klinische Pharmakologie, Medizinische, Akademie Magdeburg, DDR.
Infection. 1989 Jul-Aug;17(4):245-6. doi: 10.1007/BF01639529.
This study was conducted to examine the pharmacokinetics of doxycycline in nine healthy volunteers who had fasted overnight. Single-dose cross-over design was used. Each subject received orally 0.2 g doxycycline. The subjects swallowed the antibiotic capsules with 300 ml of water or 300 ml of fresh milk. Simultaneous ingestion of milk diminished the peak plasma concentration by 24% and the absorption by 9-53% (mean 30%). It is concluded that, like the other tetracyclines, doxycycline should not be administered together with milk.
本研究旨在检测强力霉素在9名过夜禁食的健康志愿者体内的药代动力学。采用单剂量交叉设计。每位受试者口服0.2g强力霉素。受试者用300毫升水或300毫升新鲜牛奶吞服抗生素胶囊。同时摄入牛奶使血浆峰值浓度降低了24%，吸收降低了9 - 53%（平均30%）。得出的结论是，与其他四环素类药物一样，强力霉素不应与牛奶同时服用。
