Tsukatani E
Nihon Sanka Fujinka Gakkai Zasshi. 1983 May;35(5):713-20.
To determine the significance of EPH-gestosis, the author measured the blood levels of lipid peroxides, vitamin E, thromboxane B2, and 6-Keto-prostaglandin F1 alpha. The basis for this was presence of lipid metabolism abnormalities in this disease. 1. The serum lipid peroxides level. In severe cases of EPH-gestosis, a significant increase was observed compared with normal pregnant women in the 10th month of gestation. 2. The serum V-E level. In severe cases of EPH-gestosis, there was a tendency to decrease compared with the values for the late stage of pregnancy. 3. The serum TXB2 level. In severe cases of EPH-gestosis, a significant increase was observed compared with normal pregnant women in the 10th month of gestation. 4. The serum 6-Keto-PGF1 alpha level. In severe cases of EPH-gestosis, a significant decrease was observed compared with normal pregnant women in the 10th month of gestation. 5. Relationship to the gestosis index (G-I). a. Elevation of the lipid peroxide level was noted in cases with a G.I. of 5 or higher. b. The V-E level tended to drop in cases with a G.I. of 4 or higher. c. There was a significant difference between the TXB2 levels at G.I.-3 and G.I.-4. d. The level of 6-Keto-PGF1 alpha dropped as the G.I. increased in cases with a G.I. of 4 or higher.
为确定妊娠高血压综合征（EPH - 妊娠中毒症）的重要性，作者检测了脂质过氧化物、维生素E、血栓素B2和6 - 酮 - 前列腺素F1α的血液水平。这样做的依据是该疾病存在脂质代谢异常。1. 血清脂质过氧化物水平。在EPH - 妊娠中毒症的严重病例中，与妊娠第10个月的正常孕妇相比，观察到显著升高。2. 血清维生素E水平。在EPH - 妊娠中毒症的严重病例中，与妊娠晚期的值相比有下降趋势。3. 血清血栓素B2水平。在EPH - 妊娠中毒症的严重病例中，与妊娠第10个月的正常孕妇相比，观察到显著升高。4. 血清6 - 酮 - 前列腺素F1α水平。在EPH - 妊娠中毒症的严重病例中，与妊娠第10个月的正常孕妇相比，观察到显著下降。5. 与妊娠中毒症指数（G - I）的关系。a. 在妊娠中毒症指数为5或更高的病例中，注意到脂质过氧化物水平升高。b. 在妊娠中毒症指数为4或更高的病例中，维生素E水平趋于下降。c. 妊娠中毒症指数为3和4时，血栓素B2水平存在显著差异。d. 在妊娠中毒症指数为4或更高的病例中，随着妊娠中毒症指数升高，6 - 酮 - 前列腺素F1α水平下降。
