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胰蛋白酶消化制剂中视网膜和脑血管系统的比较。

Comparison of retinal and cerebral vasculature in trypsin digest preparations.

作者信息

Cogan D G, Kuwabara T

出版信息

Br J Ophthalmol. 1984 Jan;68(1):10-2. doi: 10.1136/bjo.68.1.10.

DOI:10.1136/bjo.68.1.10
PMID:6689929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1040229/
Abstract

The trypsin digestion technique for preparing flat mounts of the retinal capillary system was modified for comparable mounts of the cerebrocortical capillaries. These preparations, supplemented by electron microscopy, showed a basic similarity between the 2 systems, but the cortical capillaries have larger diameters, more abundant collateral channels, and less regularly spaced mural cells (intramural pericytes). The cortical capillaries did not show the right-angle branching of the precapillary arteriole characteristic of some retinal vessels, but they did show in the crotches of the branches an excess basement membrane that was not present in the retinal capillaries.

摘要

用于制备视网膜毛细血管系统平铺标本的胰蛋白酶消化技术被修改,以用于制备大脑皮质毛细血管的类似标本。这些标本辅以电子显微镜观察,显示出这两个系统之间存在基本相似性,但皮质毛细血管直径更大,侧支通道更丰富,壁细胞(壁内周细胞)间距不太规则。皮质毛细血管未表现出某些视网膜血管特有的毛细血管前小动脉的直角分支,但在分支的交叉处确实显示出视网膜毛细血管中不存在的过量基底膜。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3025/1040229/19cdad650879/brjopthal00145-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3025/1040229/414f863997dc/brjopthal00145-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3025/1040229/19cdad650879/brjopthal00145-0022-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3025/1040229/414f863997dc/brjopthal00145-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3025/1040229/19cdad650879/brjopthal00145-0022-a.jpg

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本文引用的文献

1
Injection of the retinal vascular system in enucleated eyes.摘除眼球中视网膜血管系统的注射。
Br J Ophthalmol. 1949 Jun;33(6):376-9. doi: 10.1136/bjo.33.6.376.
2
Injection of the retinal vascular system in the enucleated eye in diabetic retinopathy.糖尿病视网膜病变中摘除眼球的视网膜血管系统注射
Br J Ophthalmol. 1950 Jan;34(1):38-41, illust. doi: 10.1136/bjo.34.1.38.
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Studies of retinal vascular patterns. I. Normal architecture.视网膜血管模式研究。I. 正常结构
视网膜成像在神经退行性疾病中的过去、现在和未来作用。
Prog Retin Eye Res. 2021 Jul;83:100938. doi: 10.1016/j.preteyeres.2020.100938. Epub 2021 Jan 15.
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Association of Cognitive Function and Retinal Neural and Vascular Structure in Type 1 Diabetes.1 型糖尿病患者认知功能与视网膜神经和血管结构的相关性。
J Clin Endocrinol Metab. 2021 Mar 25;106(4):1139-1149. doi: 10.1210/clinem/dgaa921.
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Automated quantification of foveal avascular zone and vascular density in Behçet's disease.贝切特病中中心凹无血管区和血管密度的自动量化。
Ir J Med Sci. 2020 Feb;189(1):349-354. doi: 10.1007/s11845-019-02051-2. Epub 2019 Jul 2.
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Non-invasive assessment of cerebral oxygenation: A comparison of retinal and transcranial oximetry.脑氧合的无创评估:视网膜血氧测定法与经颅血氧测定法的比较
PLoS One. 2018 Jan 5;13(1):e0190612. doi: 10.1371/journal.pone.0190612. eCollection 2018.
7
Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases.视网膜微血管网络改变:脑血管和神经疾病的潜在生物标志物。
Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H201-H212. doi: 10.1152/ajpheart.00201.2016. Epub 2016 Dec 6.
8
Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy?周细胞化学力学与血管生成开关:对增殖性糖尿病视网膜病变发病机制的见解?
Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3441-59. doi: 10.1167/iovs.14-13945.
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Measurement of serum and vitreous concentrations of anti-type II collagen antibody in diabetic retinopathy.糖尿病视网膜病变中抗II型胶原蛋白抗体血清和玻璃体浓度的测量。
Clin Ophthalmol. 2015 Mar 20;9:543-7. doi: 10.2147/OPTH.S75422. eCollection 2015.
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Cerebral malaria in children: using the retina to study the brain.儿童脑型疟疾:利用视网膜研究大脑。
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4
Nomenclature of pericytes. Intramural and extramural.周细胞的命名。壁内和壁外。
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