Komatsu K, Uchida K, Satoh S
Exp Neurol. 1984 Jan;83(1):33-41. doi: 10.1016/0014-4886(84)90043-8.
We investigated whether or not miniature end-plate potentials (MEPPs) play a part in neurotrophic influences. The sciatic nerve of mice, which supplies the extensor digitorum longus muscles, was cut either close to, or far from, the muscle. Denervation changes were evaluated using the resting membrane potential and dose-response curves obtained by plotting acetylcholine-induced contractures of muscles denervated 3 days earlier. The cessation of MEPPs and the manifestation of denervation changes occurred significantly later in muscles with long nerve stumps than in those with short nerve stumps. A single administration of ethidium bromide, a specific inhibitor of mitochondrial protein synthesis, accelerated the cessation of MEPPs in muscles with long nerve stumps without affecting the manifestation of denervation changes. We therefore conclude that MEPPs do not have neurotrophic effects.
我们研究了微小终板电位（MEPPs）是否在神经营养影响中发挥作用。支配趾长伸肌的小鼠坐骨神经在靠近或远离肌肉处切断。使用静息膜电位和通过绘制3天前失神经支配肌肉的乙酰胆碱诱导挛缩得到的剂量反应曲线来评估去神经变化。与短神经残端的肌肉相比，长神经残端的肌肉中MEPPs的停止和去神经变化的表现明显延迟出现。单次给予线粒体蛋白质合成的特异性抑制剂溴化乙锭，加速了长神经残端肌肉中MEPPs的停止，而不影响去神经变化的表现。因此，我们得出结论，MEPPs没有神经营养作用。
