血清和血液来源蛋白对细菌聚集的抑制作用。
Inhibition of bacterial aggregation by serum- and blood-derived proteins.
作者信息
Malamud D, Brown C, Goldman R
出版信息
Infect Immun. 1984 Jan;43(1):386-90. doi: 10.1128/iai.43.1.386-390.1984.
Abstract
Human and animal sera contain potent inhibitors of saliva-mediated aggregation of oral streptococci. The inhibitors consist of a high-molecular-weight heat-labile factor and a lower-molecular-weight heat-activated factor. The latter appears to be serum albumin. Analyses of purified blood-derived proteins indicated that several high-molecular-weight proteins (fibrinogen, fibronectin, and ferritin) were able to inhibit aggregation at low concentrations. These data suggest that high-molecular-weight proteins may modulate the aggregation process.
摘要
人和动物血清含有唾液介导的口腔链球菌聚集的强效抑制剂。这些抑制剂由一种高分子量热不稳定因子和一种低分子量热激活因子组成。后者似乎是血清白蛋白。对纯化的血液来源蛋白质的分析表明，几种高分子量蛋白质（纤维蛋白原、纤连蛋白和铁蛋白）在低浓度下能够抑制聚集。这些数据表明高分子量蛋白质可能调节聚集过程。
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