Malamud D, Goldman R, Taichman N S
Inflammation. 1983 Jun;7(2):133-44. doi: 10.1007/BF00917818.
Human parotid saliva contains agglutinins which bind to the surface of streptococci and induce the formation of bacterial aggregates. Bacterial aggregation can be blocked by proteins released from viable PMNs and platelets or by sonic extracts prepared from these cells. PMN and platelet inhibitors display characteristic differences in molecular weight, protease, and temperature sensitivity. The mechanism of action of the inhibitors appears to involve a direct interaction with the salivary agglutinins rather than with the bacteria. It is thus possible that PMN and platelet-derived products might modulate saliva-mediated bacterial aggregation and thereby influence the course of infections in the oral cavity.
人腮腺唾液中含有凝集素，可与链球菌表面结合并诱导细菌聚集体的形成。细菌聚集可被活的中性粒细胞和血小板释放的蛋白质或由这些细胞制备的超声提取物所阻断。中性粒细胞和血小板抑制剂在分子量、蛋白酶和温度敏感性方面表现出特征性差异。抑制剂的作用机制似乎涉及与唾液凝集素的直接相互作用，而不是与细菌的相互作用。因此，中性粒细胞和血小板衍生的产物可能会调节唾液介导的细菌聚集，从而影响口腔感染的进程。
