Hodges P, Gee M, Grace M, Thomson A B
J Am Diet Assoc. 1984 Jan;84(1):52-8.
A descriptive study was conducted in 23 male and 24 female adult patients with Crohn's disease to assess nutritional status. The mean daily intake of vitamin B6 and folate by the men and the women and of iron by the women was less than the Recommended Dietary Allowances. However, the range of individual intakes varied widely. According to Nutrition Canada Interpretive Standards, 50% of the female patients had inadequate intakes of iron; 13%, of riboflavin; 21%, of thiamin; and 21%, of vitamin A. The men consumed significantly less vitamin A and folate per 1,000 kcal than the women. Serum folate was the only laboratory parameter that correlated with nutrient intake; it was correlated with dietary folate, vitamin C, vitamin B12, and vitamin B6 intakes in the women only. Serum folate was low in 21% of the men and 26% of the women. Thus, a low serum folate was predictive of a potential risk of nutritional deficiency of folate and of vitamins B6, B12, and C. This study demonstrated that nutrient intake was reduced in some patients and therefore could be a factor contributing to observed nutritional deficiency in Crohn's disease.
对23名成年男性和24名成年女性克罗恩病患者进行了一项描述性研究，以评估营养状况。男性和女性维生素B6和叶酸的日均摄入量以及女性铁的日均摄入量均低于推荐膳食摄入量。然而，个体摄入量的范围差异很大。根据加拿大营养解释标准，50%的女性患者铁摄入量不足；13%的患者核黄素摄入量不足；21%的患者硫胺素摄入量不足；21%的患者维生素A摄入量不足。男性每1000千卡摄入的维生素A和叶酸明显少于女性。血清叶酸是唯一与营养素摄入量相关的实验室参数；仅在女性中，血清叶酸与膳食叶酸、维生素C、维生素B12和维生素B6的摄入量相关。21%的男性和26%的女性血清叶酸水平较低。因此，血清叶酸水平低预示着叶酸以及维生素B6、B12和C存在营养缺乏的潜在风险。这项研究表明，一些患者的营养素摄入量减少，因此可能是导致克罗恩病中观察到的营养缺乏的一个因素。
