一种新的癌基因c-raf定位于小鼠6号染色体上。
A new oncogene, c-raf, is located on mouse chromosome 6.
作者信息
Kozak C, Gunnell M A, Rapp U R
出版信息
J Virol. 1984 Jan;49(1):297-9. doi: 10.1128/JVI.49.1.297-299.1984.
Abstract
The recently described acute transforming virus 3611-MSV contains cellular sequences designated v-raf. Mouse cellular DNA contains a single-copy sequence homologous to this oncogene (c-raf), and Southern blot analysis of hamster-mouse somatic cell hybrid DNAs showed that the mouse c-raf sequence is present on chromosome 6.
摘要
最近描述的急性转化病毒3611-MSV含有被命名为v-raf的细胞序列。小鼠细胞DNA含有一个与该癌基因（c-raf）同源的单拷贝序列，对仓鼠-小鼠体细胞杂交DNA进行的Southern印迹分析表明，小鼠c-raf序列存在于6号染色体上。
相似文献
1
A new oncogene, c-raf, is located on mouse chromosome 6.一种新的癌基因c-raf定位于小鼠6号染色体上。
J Virol. 1984 Jan;49(1):297-9. doi: 10.1128/JVI.49.1.297-299.1984.
2
Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13.
Somat Cell Mol Genet. 1988 Jul;14(4):401-5. doi: 10.1007/BF01534648.
3
Genetic mapping of the mouse oncogenes c-Ha-ras-1 and c-fes to chromosome 7.小鼠癌基因c-Ha-ras-1和c-fes在7号染色体上的基因定位。
J Virol. 1983 Jul;47(1):217-20. doi: 10.1128/JVI.47.1.217-220.1983.
4
Genetic mapping of Pim-1 putative oncogene to mouse chromosome 17.
Somat Cell Mol Genet. 1986 Jan;12(1):81-8. doi: 10.1007/BF01560730.
5
The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4.raf（mil）致癌基因的人类同源基因位于人类3号和4号染色体上。
Science. 1984 Jan 6;223(4631):71-4. doi: 10.1126/science.6691137.
6
Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf.禽逆转录病毒癌基因v-mil的核苷酸序列：鼠逆转录病毒癌基因v-raf的同源物。
Nature. 1984;309(5963):85-8. doi: 10.1038/309085a0.
7
Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.位于小鼠和人类X染色体上的raf癌基因家族中的活跃转录基因。
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3934-8. doi: 10.1073/pnas.83.11.3934.
8
Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes.肉瘤和白血病病毒癌基因的四个小鼠细胞同源物的染色体定位。
Proc Natl Acad Sci U S A. 1984 Jan;81(2):525-9. doi: 10.1073/pnas.81.2.525.
9
Chromosomal assignment of the endogenous proto-oncogene C-abl.内源性原癌基因C-abl的染色体定位
Science. 1982 Dec 24;218(4579):1317-9. doi: 10.1126/science.6293057.
10
Genetic mapping of the mouse c-fms proto-oncogene to chromosome 18.小鼠c-fms原癌基因的遗传定位至第18号染色体。
J Virol. 1988 Mar;62(3):1055-6. doi: 10.1128/JVI.62.3.1055-1056.1988.
引用本文的文献
1
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy.MAPK 和 AMPK 信号通路：在肿瘤靶向治疗中的相互作用和影响。
J Hematol Oncol. 2020 Aug 17;13(1):113. doi: 10.1186/s13045-020-00949-4.
2
Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy.针对癌症治疗的异常 RAS/RAF/MEK/ERK 信号通路。
Cells. 2020 Jan 13;9(1):198. doi: 10.3390/cells9010198.
3
Oncogene-directed small molecule inhibitors for the treatment of cutaneous melanoma.用于治疗皮肤黑色素瘤的癌基因导向小分子抑制剂。
Melanoma Manag. 2015 May;2(2):133-147. doi: 10.2217/mmt.15.5. Epub 2015 May 18.
4
Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF.CRAF 缺失的小鼠海马神经祖细胞神经元成熟受损。
PLoS One. 2018 Mar 28;13(3):e0192067. doi: 10.1371/journal.pone.0192067. eCollection 2018.
5
Decoding the full picture of Raf1 function based on its interacting proteins.基于Raf1相互作用蛋白解读其完整功能图景。
Oncotarget. 2017 Jul 18;8(40):68329-68337. doi: 10.18632/oncotarget.19353. eCollection 2017 Sep 15.
6
CRISPR/Cas9 and cancer targets: future possibilities and present challenges.CRISPR/Cas9与癌症靶点：未来可能性与当前挑战
Oncotarget. 2016 Mar 15;7(11):12305-17. doi: 10.18632/oncotarget.7104.
7
Regulation of RAF protein kinases in ERK signalling.RAF 蛋白激酶在 ERK 信号转导中的调控。
Nat Rev Mol Cell Biol. 2015 May;16(5):281-98. doi: 10.1038/nrm3979.
8
Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond.靶向RAF激酶用于癌症治疗：BRAF突变型黑色素瘤及其他情况。
Nat Rev Cancer. 2014 Jul;14(7):455-67. doi: 10.1038/nrc3760.
9
Conserved linkage of neurotrophin-3 and von Willebrand factor on mouse chromosome 6.神经营养因子-3与血管性血友病因子在小鼠6号染色体上的保守连锁。
Mamm Genome. 1993;4(6):343-5. doi: 10.1007/BF00357095.
10
The William Allan Memorial Award address: Reverse genetics and beyond.威廉·艾伦纪念奖演讲：反向遗传学及其他
Am J Hum Genet. 1984 Sep;36(5):944-53.
本文引用的文献
1
Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas.小鼠c-myc癌基因位于15号染色体上，在浆细胞瘤中易位至12号染色体。
Science. 1982 Dec 24;218(4579):1319-21. doi: 10.1126/science.7146913.
2
Chromosomal localization of the Moloney sarcoma virus mouse cellular (c-mos) sequence.莫洛尼肉瘤病毒小鼠细胞（c-mos）序列的染色体定位。
J Virol. 1982 Nov;44(2):752-4. doi: 10.1128/JVI.44.2.752-754.1982.
3
Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.人类c-myc癌基因位于8号染色体上，该区域在伯基特淋巴瘤细胞中发生易位。
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7824-7. doi: 10.1073/pnas.79.24.7824.
4
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia.在慢性粒细胞白血病中，一种细胞癌基因易位至费城染色体。
Nature. 1982 Dec 23;300(5894):765-7. doi: 10.1038/300765a0.
5
Genetic mapping of the ecotropic virus-inducing locus Akv-2 of the AKR mouse.AKR小鼠亲嗜性病毒诱导位点Akv-2的基因定位
J Exp Med. 1980 Nov 1;152(5):1419-23. doi: 10.1084/jem.152.5.1419.
6
Genetic mapping of the mouse oncogenes c-Ha-ras-1 and c-fes to chromosome 7.小鼠癌基因c-Ha-ras-1和c-fes在7号染色体上的基因定位。
J Virol. 1983 Jul;47(1):217-20. doi: 10.1128/JVI.47.1.217-220.1983.
7
Human oncogene locations and chromosome aberrations.人类癌基因定位与染色体畸变。
Nature. 1983 Jan 27;301(5898):290-1. doi: 10.1038/301290a0.
8
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.在人类伯基特淋巴瘤和鼠浆细胞瘤细胞中，c-myc基因易位至免疫球蛋白重链基因座。
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7837-41. doi: 10.1073/pnas.79.24.7837.
9
Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men.小鼠和人类中特定染色体易位与B细胞源性肿瘤的发生
Cell. 1983 Feb;32(2):311-5. doi: 10.1016/0092-8674(83)90449-x.
10
Cellular oncogenes and retroviruses.细胞癌基因与逆转录病毒。
Annu Rev Biochem. 1983;52:301-54. doi: 10.1146/annurev.bi.52.070183.001505.
Zotero 插件