Crews S, Barth R, Hood L, Prehn J, Calame K
Science. 1982 Dec 24;218(4579):1319-21. doi: 10.1126/science.7146913.
Hybridization studies with viral oncogene probes indicate that c-myc, the cellular gene homologous to the transforming gene of avian myelocytomatosis virus, resides on mouse chromosome 15 and in many plasmacytomas is translocated to the antibody heavy chain gene locus on chromosome 12. The transcriptional orientation of the translocated c-myc sequence is opposite the orientation of the adjacent C alpha gene that codes for the heavy chain of immunoglobulin A. The translocated c-myc sequence is not the same oncogene detected in urine plasmacytomas by the NIH-3T3 cell transformation assay.
用病毒癌基因探针进行的杂交研究表明，c-myc是与禽成髓细胞瘤病毒转化基因同源的细胞基因，定位于小鼠15号染色体上，在许多浆细胞瘤中易位至12号染色体上的抗体重链基因座。易位的c-myc序列的转录方向与编码免疫球蛋白A重链的相邻Cα基因的方向相反。易位的c-myc序列与通过NIH-3T3细胞转化试验在尿浆细胞瘤中检测到的癌基因不同。
