Arnow P M, Smaron M, Ormiste V
JAMA. 1984 Jan 27;251(4):505-7.
An epidemiologic investigation, initiated when Brucella melitensis infection was detected in a high school student, identified five unrecognized cases in classmates. Before the investigation, four infected students had symptoms of brucellosis for one to ten weeks, made nine visits to physicians, and were confined to the school infirmary or hospitals for 27 days. The other two students were asymptomatic when Brucella agglutination testing demonstrated elevated titers, and treatment was quickly instituted when symptoms occurred. Travel to Spain was implicated because cases were clustered in six of 27 travelers compared with none of 23 control students. Food-history questionnaires showed more frequent consumption of cheese by infected than noninfected travelers. This cluster of cases demonstrates the risk of brucellosis in travelers to endemic areas and illustrates the value of an epidemiologic investigation of cases.
在一名高中生被检测出感染羊种布鲁氏菌后展开的一项流行病学调查，在其同学中发现了5例此前未被识别的病例。调查前，4名受感染学生出现布鲁氏菌病症状达1至10周，看了9次医生，并在学校医务室或医院住院27天。另外两名学生在布鲁氏菌凝集试验显示滴度升高时无症状，症状出现后迅速接受了治疗。前往西班牙旅行被认为是病因，因为27名旅行者中有6人发病，而23名对照学生中无人发病。食物史调查问卷显示，受感染旅行者食用奶酪的频率高于未受感染的旅行者。这一系列病例表明前往疫区的旅行者有感染布鲁氏菌病的风险，并说明了对病例进行流行病学调查的价值。
