Orangio G R, Pitlick S D, Della Latta P, Mandel L J, Marino C, Guarneri J J, Giron J A, Margolis I B
Ann Surg. 1984 Jan;199(1):97-100. doi: 10.1097/00000658-198401000-00016.
Thirty-four parenteral drug abusers admitted with soft tissue infections underwent bacteriologic and immunologic evaluation. Staphylococcus aureus and beta hemolytic streptococci were the most common organisms recovered. Enteric gram negative aerobes and oral flora were common and enteric anaerobes rare. Absolute lymphopenia and elevations in the IgA, IgG and IgM fractions of the immunoglobulins were common as were false positive VDRL examinations. Cutaneous anergy was found in 83% of the group and 70% of a simultaneously noninfected addict group. Staphylococcal carriage was frequent. Because of variation in the flora between this and other reported groups, ongoing bacteriologic surveillance could be a useful guide to initial antibiotic therapy. Differences in the pattern of immune reaction in this group when compared to different addict groups suggest a difference in antigenic stimulation, possibly as a result of differences in bacteriologic exposure.
34名因软组织感染入院的注射吸毒者接受了细菌学和免疫学评估。金黄色葡萄球菌和β溶血性链球菌是最常见的分离出的微生物。肠道革兰氏阴性需氧菌和口腔菌群很常见，而肠道厌氧菌很少见。绝对淋巴细胞减少以及免疫球蛋白的IgA、IgG和IgM组分升高很常见，梅毒血清试验假阳性也很常见。该组83%的人以及同时期一个未感染成瘾者组70%的人存在皮肤无反应性。葡萄球菌携带情况很常见。由于该组与其他报道组之间菌群存在差异，持续的细菌学监测可能是初始抗生素治疗的有用指导。与不同成瘾者组相比，该组免疫反应模式的差异表明抗原刺激存在差异，可能是由于细菌接触情况不同所致。
