Weissman M M, Gershon E S, Kidd K K, Prusoff B A, Leckman J F, Dibble E, Hamovit J, Thompson W D, Pauls D L, Guroff J J
Arch Gen Psychiatry. 1984 Jan;41(1):13-21. doi: 10.1001/archpsyc.1984.01790120015003.
A family study of psychiatric disorders in 2,003 first-degree relatives of 335 probands found increased rates of bipolar I disorder and major depression (MD) in the relatives of probands with bipolar disorder and increased rates of MD in the relatives of probands with MD. There was a similarity in rates of affective disorders in the relatives of ambulatory and of hospitalized depressed probands (suggesting that ambulatory depressed patients may be as suitable as hospitalized ones for biological studies) and a comparability of rates of illness in relatives between centers for most disorders when comparable diagnostic criteria and procedures were used.
一项针对335名先证者的2003名一级亲属的精神疾病家族研究发现，双相I型障碍和重度抑郁症（MD）在先证者患有双相情感障碍的亲属中发病率增加，而MD在先证者患有MD的亲属中发病率增加。门诊和住院的抑郁症先证者的亲属中情感障碍的发病率相似（这表明门诊抑郁症患者可能与住院患者一样适合进行生物学研究），并且当使用可比的诊断标准和程序时，大多数疾病在各中心亲属中的发病率具有可比性。
