Murphy G E, Simons A D, Wetzel R D, Lustman P J
Arch Gen Psychiatry. 1984 Jan;41(1):33-41. doi: 10.1001/archpsyc.1984.01790120037006.
Eight-seven moderately to severely depressed psychiatric outpatients were randomly assigned to 12 weeks of cognitive therapy (CT) (n = 24), pharmacotherapy (n = 24), CT plus pharmacotherapy (n = 22), or CT plus active placebo (n = 17). Seventy patients completed the treatment protocol. Seventeen dropped out before the end of the treatment period. Patients who completed treatment showed significant improvement in mean scores on two common measures of severity of depression (the Beck Depression Inventory and the Hamilton Rating Scale for Depression) between evaluation and termination. Improvement did not differ as a function of the different treatment modalities. Inclusion of dropout patients' end-point scores did not alter these results. Treatment gains in all groups were maintained at one-month follow-up assessment. A portion of this study replicated an earlier study. While the results were not identical, they indicated that either CT or antidepressant drug treatment can be effective in treating outpatients with primary, nonbipolar depression of moderate or greater severity. Combining treatments did not lead either to additive effects or negative interactions.
八十七名中度至重度抑郁的精神科门诊患者被随机分配接受为期12周的认知疗法（CT）（n = 24）、药物治疗（n = 24）、CT联合药物治疗（n = 22）或CT联合活性安慰剂治疗（n = 17）。七十名患者完成了治疗方案。十七名患者在治疗期结束前退出。完成治疗的患者在评估和治疗结束之间，在两项常见的抑郁严重程度测量指标（贝克抑郁量表和汉密尔顿抑郁评定量表）上的平均得分有显著改善。改善情况不因不同的治疗方式而有所不同。纳入退出患者的终点分数并未改变这些结果。所有组的治疗效果在1个月的随访评估中得以维持。本研究的一部分重复了一项早期研究。虽然结果并不完全相同，但表明CT或抗抑郁药物治疗均可有效治疗中度或更严重的原发性非双相抑郁门诊患者。联合治疗既未产生相加效应，也未产生负面相互作用。
