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黄疸光疗：微流细胞光度法揭示冈恩大鼠对光的快速胆汁反应。

Jaundice phototherapy: micro flow-cell photometry reveals rapid biliary response of Gunn rats to light.

作者信息

McDonagh A F, Ramonas L M

出版信息

Science. 1978 Sep 1;201(4358):829-31. doi: 10.1126/science.581101.

DOI:10.1126/science.581101
PMID:581101
Abstract

Hepatic pigment clearance in rats can be followed continuously with photometric detectors designed for high-pressure liquid chromatography. This method showed that light has a fast effect on bilirubin metabolism in homozygous Gunn rats, even at low doses and intensities. This is consistent with geometric isomerization of bilirubin IXalpha as a primary step in phototherapy.

摘要

利用为高压液相色谱设计的光度检测器，可以持续跟踪大鼠肝脏色素清除情况。该方法表明，即使在低剂量和低强度下，光照对纯合子Gunn大鼠的胆红素代谢也有快速影响。这与胆红素IXα的几何异构化作为光疗的首要步骤是一致的。

相似文献

1
Jaundice phototherapy: micro flow-cell photometry reveals rapid biliary response of Gunn rats to light.黄疸光疗：微流细胞光度法揭示冈恩大鼠对光的快速胆汁反应。
Science. 1978 Sep 1;201(4358):829-31. doi: 10.1126/science.581101.
2
Demonstration of a geometric isomer of bilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy.一名高胆红素血症新生儿血清中胆红素-IXα几何异构体的证实及黄疸光疗机制
Biochem J. 1980 Sep 15;190(3):533-6. doi: 10.1042/bj1900533.
3
Excretion of administered and endogenous photobilirubins in the bile of the jaundice gunn rat.黄疸Gunn大鼠胆汁中注入的和内源性光胆红素的排泄情况。
J Clin Invest. 1981 Jul;68(1):134-41. doi: 10.1172/jci110229.
4
Blue light and bilirubin excretion.蓝光与胆红素排泄
Science. 1980 Apr 11;208(4440):145-51. doi: 10.1126/science.7361112.
5
Phototherapy in a new light.
Pediatr Clin North Am. 1986 Jun;33(3):603-20. doi: 10.1016/s0031-3955(16)36045-x.
6
Bilirubin dynamics in the Gunn rat. Dose response of intermittent and continuous phototherapy.冈恩大鼠的胆红素动态变化。间歇性和持续性光疗的剂量反应。
Biol Neonate. 1980;38(1-2):106-12. doi: 10.1159/000241349.
7
Effect of phototherapy on serum bilirubin levels and red blood cell survival in congenitally jaundiced Gunn rats.光疗对先天性黄疸Gunn大鼠血清胆红素水平及红细胞存活的影响。
J Lab Clin Med. 1978 Aug;92(2):221-7.
8
Metabolism of bilirubin and its photoisomers in newborn infants during phototherapy.新生儿光疗期间胆红素及其光异构体的代谢
J Biochem. 1986 Sep;100(3):789-95. doi: 10.1093/oxfordjournals.jbchem.a121772.
9
[Data on phototherapy in neonatal jaundice].[新生儿黄疸光疗的数据]
Arch Fr Pediatr. 1980 Jun;37(6):407-14.
10
Hepatic excretion of circulating bilirubin photoproducts in the Gunn rat.冈恩大鼠体内循环胆红素光产物的肝脏排泄
J Clin Invest. 1980 Nov;66(5):1182-5. doi: 10.1172/JCI109951.

引用本文的文献

1
Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species.与人相比，绿光发光二极管下胆红素光化学反应的特点。在动物物种中。
Sci Rep. 2021 Mar 18;11(1):6391. doi: 10.1038/s41598-021-85632-5.
2
Demonstration of a geometric isomer of bilirubin-IX alpha in the serum of a hyperbilirubinaemic newborn infant and the mechanism of jaundice phototherapy.一名高胆红素血症新生儿血清中胆红素-IXα几何异构体的证实及黄疸光疗机制
Biochem J. 1980 Sep 15;190(3):533-6. doi: 10.1042/bj1900533.
3
Hepatic excretion of circulating bilirubin photoproducts in the Gunn rat.
冈恩大鼠体内循环胆红素光产物的肝脏排泄
J Clin Invest. 1980 Nov;66(5):1182-5. doi: 10.1172/JCI109951.
4
Kinetics of biliary excretion of the main two bilirubin photoproducts after injection into Gunn rats.注射到冈恩大鼠体内后两种主要胆红素光产物的胆汁排泄动力学。
Biochem J. 1981 Jul 15;198(1):107-12. doi: 10.1042/bj1980107.
5
Photoisomerized bilirubin in blood from infants receiving phototherapy.接受光疗的婴儿血液中的光异构化胆红素。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1882-6. doi: 10.1073/pnas.78.3.1882.